Abstract
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir.
| Original language | English |
|---|---|
| Pages (from-to) | 153-156 |
| Number of pages | 4 |
| Journal | Clinical Neurology and Neurosurgery |
| Volume | 112 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2010 Feb |
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Keywords
- Cidofovir
- Heerfordt syndrome
- JC virus
- Progressive multifocal leukoencephalopathy
- Sarcoidosis
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir. / Yagi, Takuya; Hattori, Hidenori; Ohira, Masayuki; Nakamichi, Kazuo; Takayama-Ito, Mutsuyo; Saijo, Masayuki; Shimizu, Toshihiko; Ito, Daisuke; Takahashi, Kazushi; Suzuki, Norihiro.
In: Clinical Neurology and Neurosurgery, Vol. 112, No. 2, 02.2010, p. 153-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir
AU - Yagi, Takuya
AU - Hattori, Hidenori
AU - Ohira, Masayuki
AU - Nakamichi, Kazuo
AU - Takayama-Ito, Mutsuyo
AU - Saijo, Masayuki
AU - Shimizu, Toshihiko
AU - Ito, Daisuke
AU - Takahashi, Kazushi
AU - Suzuki, Norihiro
PY - 2010/2
Y1 - 2010/2
N2 - Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir.
AB - Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir.
KW - Cidofovir
KW - Heerfordt syndrome
KW - JC virus
KW - Progressive multifocal leukoencephalopathy
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=74149084951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74149084951&partnerID=8YFLogxK
U2 - 10.1016/j.clineuro.2009.10.005
DO - 10.1016/j.clineuro.2009.10.005
M3 - Article
C2 - 19892460
AN - SCOPUS:74149084951
VL - 112
SP - 153
EP - 156
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
SN - 0303-8467
IS - 2
ER -