Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir

Takuya Yagi, Hidenori Hattori, Masayuki Ohira, Kazuo Nakamichi, Mutsuyo Takayama-Ito, Masayuki Saijo, Toshihiko Shimizu, Daisuke Ito, Kazushi Takahashi, Norihiro Suzuki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalClinical Neurology and Neurosurgery
Volume112
Issue number2
DOIs
Publication statusPublished - 2010 Feb

Fingerprint

Uveoparotid Fever
Progressive Multifocal Leukoencephalopathy
Sarcoidosis
Steroids
JC Virus
Demyelinating Diseases
Hematologic Neoplasms
Immunosuppressive Agents
Immunosuppression
Autoimmune Diseases
Antiviral Agents
Therapeutics
Central Nervous System
Transplantation
Mortality
cidofovir

Keywords

  • Cidofovir
  • Heerfordt syndrome
  • JC virus
  • Progressive multifocal leukoencephalopathy
  • Sarcoidosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir. / Yagi, Takuya; Hattori, Hidenori; Ohira, Masayuki; Nakamichi, Kazuo; Takayama-Ito, Mutsuyo; Saijo, Masayuki; Shimizu, Toshihiko; Ito, Daisuke; Takahashi, Kazushi; Suzuki, Norihiro.

In: Clinical Neurology and Neurosurgery, Vol. 112, No. 2, 02.2010, p. 153-156.

Research output: Contribution to journalArticle

Yagi, Takuya ; Hattori, Hidenori ; Ohira, Masayuki ; Nakamichi, Kazuo ; Takayama-Ito, Mutsuyo ; Saijo, Masayuki ; Shimizu, Toshihiko ; Ito, Daisuke ; Takahashi, Kazushi ; Suzuki, Norihiro. / Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir. In: Clinical Neurology and Neurosurgery. 2010 ; Vol. 112, No. 2. pp. 153-156.
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