Prolactin, renin and catecholamines in essential hypertension

Takao Saruta, Hiroshi Kawabe, Masaki Fujimaki, Syusaku Nagahama, Ikuo Saito, Kazuoki Kondo

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17 Citations (Scopus)

Abstract

In 40 male patients with essential hypertension less than the age of 36 years, the plasma prolactin (PRL), plasma renin activity (PRA) and plasma catecholamines (noradrenaline (NA) and adrenaline (A)) were determined simultaneously. Those levels were significantly increased compared to the levels in 14 age-matched healthy male control subjects. Furthermore, there were significant correlations between the PRL and plasma NA or PRA (p<0.05 in each case), and between the PRA and plasma NA (p<0.05). However, no significant relationships were observed between systolic or diastolic blood pressure and PRL, plasma NA or PRA. These findings indicate that the central dopaminergic activity is reduced in a number of young adults with essential hypertension, and that in the patients with the reduced central dopaminergic actvity, the peripheral sympathetic activity is stimulated and PRA is also increased probably due to the increased peripheral sympathetic activity, and the possibility exists that such changes are related to the development of hypertension.

Original languageEnglish
Pages (from-to)531-541
Number of pages11
JournalClinical and Experimental Hypertension
VolumeA5
Issue number4
DOIs
Publication statusPublished - 1983 Jan 1

Keywords

  • Epinephrine
  • Hypertension
  • Norepinephrine
  • Prolactin
  • Renin

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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    Saruta, T., Kawabe, H., Fujimaki, M., Nagahama, S., Saito, I., & Kondo, K. (1983). Prolactin, renin and catecholamines in essential hypertension. Clinical and Experimental Hypertension, A5(4), 531-541. https://doi.org/10.3109/10641968309081790