Proliferation of neuroblasts in the adult brain

Role of diversin

Yuki Hirota, Kazunobu Sawamoto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.

Original languageEnglish
Title of host publicationTumors of the Central Nervous System, Volume 9
Subtitle of host publicationLymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas
PublisherSpringer Netherlands
Pages177-183
Number of pages7
ISBN (Electronic)9789400754881
ISBN (Print)9789400754874
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

Fingerprint

Neural Stem Cells
Lateral Ventricles
Neurogenesis
Brain
Stem Cells
Neurons
Wnt Signaling Pathway
Olfactory Bulb
Interneurons
Brain Injuries
Cell Movement
Rodentia
Homeostasis
diversin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hirota, Y., & Sawamoto, K. (2012). Proliferation of neuroblasts in the adult brain: Role of diversin. In Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas (pp. 177-183). Springer Netherlands. https://doi.org/10.1007/978-94-007-5488-1_20

Proliferation of neuroblasts in the adult brain : Role of diversin. / Hirota, Yuki; Sawamoto, Kazunobu.

Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, 2012. p. 177-183.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hirota, Y & Sawamoto, K 2012, Proliferation of neuroblasts in the adult brain: Role of diversin. in Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, pp. 177-183. https://doi.org/10.1007/978-94-007-5488-1_20
Hirota Y, Sawamoto K. Proliferation of neuroblasts in the adult brain: Role of diversin. In Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands. 2012. p. 177-183 https://doi.org/10.1007/978-94-007-5488-1_20
Hirota, Yuki ; Sawamoto, Kazunobu. / Proliferation of neuroblasts in the adult brain : Role of diversin. Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, 2012. pp. 177-183
@inbook{81d66310f0134c00b1c460498df65909,
title = "Proliferation of neuroblasts in the adult brain: Role of diversin",
abstract = "The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.",
author = "Yuki Hirota and Kazunobu Sawamoto",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/978-94-007-5488-1_20",
language = "English",
isbn = "9789400754874",
pages = "177--183",
booktitle = "Tumors of the Central Nervous System, Volume 9",
publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Proliferation of neuroblasts in the adult brain

T2 - Role of diversin

AU - Hirota, Yuki

AU - Sawamoto, Kazunobu

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.

AB - The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.

UR - http://www.scopus.com/inward/record.url?scp=85031428068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031428068&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-5488-1_20

DO - 10.1007/978-94-007-5488-1_20

M3 - Chapter

SN - 9789400754874

SP - 177

EP - 183

BT - Tumors of the Central Nervous System, Volume 9

PB - Springer Netherlands

ER -