Proliferation of neuroblasts in the adult brain: Role of diversin

Yuki Hirota; Kazunobu Sawamoto

doi:10.1007/978-94-007-5488-1_20

Proliferation of neuroblasts in the adult brain: Role of diversin

Yuki Hirota, Kazunobu Sawamoto

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.

Original language	English
Title of host publication	Tumors of the Central Nervous System, Volume 9
Subtitle of host publication	Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas
Publisher	Springer Netherlands
Pages	177-183
Number of pages	7
ISBN (Electronic)	9789400754881
ISBN (Print)	9789400754874
DOIs	https://doi.org/10.1007/978-94-007-5488-1_20
Publication status	Published - 2012 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-94-007-5488-1_20

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Hirota, Y., & Sawamoto, K. (2012). Proliferation of neuroblasts in the adult brain: Role of diversin. In Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas (pp. 177-183). Springer Netherlands. https://doi.org/10.1007/978-94-007-5488-1_20

Proliferation of neuroblasts in the adult brain: Role of diversin. / Hirota, Yuki; Sawamoto, Kazunobu.
Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, 2012. p. 177-183.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Hirota, Y & Sawamoto, K 2012, Proliferation of neuroblasts in the adult brain: Role of diversin. in Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, pp. 177-183. https://doi.org/10.1007/978-94-007-5488-1_20

Hirota Y, Sawamoto K. Proliferation of neuroblasts in the adult brain: Role of diversin. In Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands. 2012. p. 177-183 doi: 10.1007/978-94-007-5488-1_20

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Proliferation of neuroblasts in the adult brain: Role of diversin

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