Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis

Shin ichi Komiyama, Daisuke Aoki, Yukio Katsuki, Shiro Nozawa

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Objective: To investigate differences in the biological characteristics of ovarian clear cell adenocarcinoma based on the presence/absence of endometriosis and tumor proliferative activity. Methods: Stage I ovarian clear cell adenocarcinoma patients were divided into groups with and without endometriosis, and immunohistochemical expression of proliferating cell nuclear antigen was determined in surgical specimens. Then xenograft models of human ovarian clear cell adenocarcinoma with or without human ectopic endometrium were created in severe combined immunodeficiency mice, and tumor growth was assessed from the wet weight and the bromodeoxyuridine uptake. Furthermore, a xenograft model of human endometriosis was made with or without ovarian clear cell adenocarcinoma and cytokine production was investigated. Results: The proliferating cell nuclear antigen labeling index was significantly lower in the tumors of patients with endometriosis compared to the tumors of patients without endometriosis. In tumor-bearing mice, the tumor weight and bromodeoxyuridine uptake were both significantly lower when ovarian clear cell adenocarcinoma was associated with endometriosis than in its absence. Release of transforming growth factor-β1 and interleukin-6 from the ectopic human endometrium was greater in the presence of clear cell adenocarcinoma than without it, and transforming growth factor-β1 levels showed a significant difference. Conclusion: The proliferative activity of early ovarian clear cell adenocarcinoma seems to depend on the association of this cancer with endometriosis. When endometriosis is associated with ovarian clear cell adenocarcinoma, there is a change of its cytokine production that may inhibit tumor growth.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - 2006 Jul 1


  • Bromodeoxyuridine
  • Endometriosis
  • Ovarian clear cell adenocarcinoma
  • Proliferating cell nuclear antigen
  • SCID mouse
  • Stage I
  • Transforming growth factor-beta 1
  • Xenograft

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


Dive into the research topics of 'Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis'. Together they form a unique fingerprint.

Cite this