Prolonged Mycoplasma pneumoniae infection in an elderly patient with community-acquired pneumonia

Takashi Takahashi, Miyuki Morozumi, Takafumi Okada, Naoko Chiba, Ryoko Asami, Somay Y. Murayama, Kimiko Ubukata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An 81-year-old woman with no underlying systemic illness was hospitalized with fever, muscle weakness, and sputum without cough for 2 days. Chest imaging showed consolidation in the left lower lobe. Real-time polymerase chain reaction (PCR) for six respiratory bacteria and 12 respiratory viruses performed on sputum obtained on admission showed Mycoplasma pneumoniae DNA, with no evidence of other pathogens. M. pneumoniae was confirmed to be the causative agent by serologic data. Variation of mycoplasma quantity in subsequent sputa was analyzed because of persistent sputum production despite treatment with minocycline. Mycoplasma DNA gradually decreased, becoming undetectable 1 week after the completion of 2 weeks of minocycline therapy. Two weeks after the completion of the minocycline therapy, mycoplasma DNA in sputum was strongly detectable again, and oral treatment with clarithromycin was initiated. No pathogen DNA was detected during 2 weeks of clarithromycin therapy or at 2 weeks after completion of this therapy. Although susceptibility tests on three isolates (on admission, 1 week after starting minocycline, and 2 weeks after minocycline cessation), showed no resistance to minocycline or clarithromycin, the infection was, nonetheless, prolonged. Some elderly subjects with mycoplasma pneumonia may show a longer course than that in young persons with pneumonia.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalJournal of Infection and Chemotherapy
Volume15
Issue number4
DOIs
Publication statusPublished - 2009 Aug
Externally publishedYes

Fingerprint

Mycoplasma pneumoniae
Minocycline
Sputum
Pneumonia
Clarithromycin
Mycoplasma
Infection
DNA
Mycoplasma Pneumonia
Therapeutics
Muscle Weakness
Cough
Genetic Therapy
Real-Time Polymerase Chain Reaction
Fever
Thorax
Viruses
Bacteria

Keywords

  • Community-acquired pneumonia
  • Drug susceptibility
  • Elderly
  • Mycoplasma pneumoniae
  • Real-time PCR

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Prolonged Mycoplasma pneumoniae infection in an elderly patient with community-acquired pneumonia. / Takahashi, Takashi; Morozumi, Miyuki; Okada, Takafumi; Chiba, Naoko; Asami, Ryoko; Murayama, Somay Y.; Ubukata, Kimiko.

In: Journal of Infection and Chemotherapy, Vol. 15, No. 4, 08.2009, p. 243-247.

Research output: Contribution to journalArticle

Takahashi, Takashi ; Morozumi, Miyuki ; Okada, Takafumi ; Chiba, Naoko ; Asami, Ryoko ; Murayama, Somay Y. ; Ubukata, Kimiko. / Prolonged Mycoplasma pneumoniae infection in an elderly patient with community-acquired pneumonia. In: Journal of Infection and Chemotherapy. 2009 ; Vol. 15, No. 4. pp. 243-247.
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