Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma

Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Akira Miyajima, Ken Nakagawa, Mototsugu Oya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). Patients and methods We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10–12 mmHg to extirpation of the kidney. Results During the median follow-up of 31.1 months, 61 (47.3%) had subsequent IVR after LRNU. Multivariate analysis revealed that prolonged pneumoperitoneum time (HR = 1.81, p = 0.025) and presence of lymphovascular invasion (LVI) (HR = 1.53, p = 0.006) were independent risk factors for subsequent IVR. The 3-year and 5-year IVR free survival rates were 43.7% and 21.8% in patients with a prolonged pneumoperitoneum time of ≥150 min, which were significantly lower than those in their counterparts (59.0% and 48.3%, respectively, p = 0.024). The subsequent IVR rates were 27.3% for a pneumoperitoneum time of <90 min, 35.8% for that of 90–150 min, 55.0% for that of 150–210 min, 61.1% for that of 210–270 min, and 85.7% for that of >270 min. Conclusions Prolongation of pneumoperitoneum time and presence of LVI might be associated with higher risk of subsequent IVR in UTUC patients who underwent LRNU.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalSurgical Oncology
Volume26
Issue number1
DOIs
Publication statusPublished - 2017 Mar 1

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Pneumoperitoneum
Carcinoma
Recurrence
Videotape Recording
Multivariate Analysis
Survival Rate
Gases
Kidney
Pressure

Keywords

  • Intravesical recurrence
  • Lymphovascular invasion
  • Pneumoperitoneum time
  • Upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma. / Shigeta, Keisuke; Kikuchi, Eiji; Hagiwara, Masayuki; Ando, Toshiyuki; Mizuno, Ryuichi; Miyajima, Akira; Nakagawa, Ken; Oya, Mototsugu.

In: Surgical Oncology, Vol. 26, No. 1, 01.03.2017, p. 73-79.

Research output: Contribution to journalArticle

Shigeta, Keisuke ; Kikuchi, Eiji ; Hagiwara, Masayuki ; Ando, Toshiyuki ; Mizuno, Ryuichi ; Miyajima, Akira ; Nakagawa, Ken ; Oya, Mototsugu. / Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma. In: Surgical Oncology. 2017 ; Vol. 26, No. 1. pp. 73-79.
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abstract = "Objective To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). Patients and methods We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10–12 mmHg to extirpation of the kidney. Results During the median follow-up of 31.1 months, 61 (47.3{\%}) had subsequent IVR after LRNU. Multivariate analysis revealed that prolonged pneumoperitoneum time (HR = 1.81, p = 0.025) and presence of lymphovascular invasion (LVI) (HR = 1.53, p = 0.006) were independent risk factors for subsequent IVR. The 3-year and 5-year IVR free survival rates were 43.7{\%} and 21.8{\%} in patients with a prolonged pneumoperitoneum time of ≥150 min, which were significantly lower than those in their counterparts (59.0{\%} and 48.3{\%}, respectively, p = 0.024). The subsequent IVR rates were 27.3{\%} for a pneumoperitoneum time of <90 min, 35.8{\%} for that of 90–150 min, 55.0{\%} for that of 150–210 min, 61.1{\%} for that of 210–270 min, and 85.7{\%} for that of >270 min. Conclusions Prolongation of pneumoperitoneum time and presence of LVI might be associated with higher risk of subsequent IVR in UTUC patients who underwent LRNU.",
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T1 - Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma

AU - Shigeta, Keisuke

AU - Kikuchi, Eiji

AU - Hagiwara, Masayuki

AU - Ando, Toshiyuki

AU - Mizuno, Ryuichi

AU - Miyajima, Akira

AU - Nakagawa, Ken

AU - Oya, Mototsugu

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). Patients and methods We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10–12 mmHg to extirpation of the kidney. Results During the median follow-up of 31.1 months, 61 (47.3%) had subsequent IVR after LRNU. Multivariate analysis revealed that prolonged pneumoperitoneum time (HR = 1.81, p = 0.025) and presence of lymphovascular invasion (LVI) (HR = 1.53, p = 0.006) were independent risk factors for subsequent IVR. The 3-year and 5-year IVR free survival rates were 43.7% and 21.8% in patients with a prolonged pneumoperitoneum time of ≥150 min, which were significantly lower than those in their counterparts (59.0% and 48.3%, respectively, p = 0.024). The subsequent IVR rates were 27.3% for a pneumoperitoneum time of <90 min, 35.8% for that of 90–150 min, 55.0% for that of 150–210 min, 61.1% for that of 210–270 min, and 85.7% for that of >270 min. Conclusions Prolongation of pneumoperitoneum time and presence of LVI might be associated with higher risk of subsequent IVR in UTUC patients who underwent LRNU.

AB - Objective To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). Patients and methods We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10–12 mmHg to extirpation of the kidney. Results During the median follow-up of 31.1 months, 61 (47.3%) had subsequent IVR after LRNU. Multivariate analysis revealed that prolonged pneumoperitoneum time (HR = 1.81, p = 0.025) and presence of lymphovascular invasion (LVI) (HR = 1.53, p = 0.006) were independent risk factors for subsequent IVR. The 3-year and 5-year IVR free survival rates were 43.7% and 21.8% in patients with a prolonged pneumoperitoneum time of ≥150 min, which were significantly lower than those in their counterparts (59.0% and 48.3%, respectively, p = 0.024). The subsequent IVR rates were 27.3% for a pneumoperitoneum time of <90 min, 35.8% for that of 90–150 min, 55.0% for that of 150–210 min, 61.1% for that of 210–270 min, and 85.7% for that of >270 min. Conclusions Prolongation of pneumoperitoneum time and presence of LVI might be associated with higher risk of subsequent IVR in UTUC patients who underwent LRNU.

KW - Intravesical recurrence

KW - Lymphovascular invasion

KW - Pneumoperitoneum time

KW - Upper tract urothelial carcinoma

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