Prolonged QT interval in alcoholic autonomic nervous dysfunction

A. Yokoyama, H. Ishii, T. Takagi, S. Hori, S. Matsushita, S. Onishi, Fuminori Katsukawa, I. Takei, Shinzo Kato, K. Maruyama, M. Tsuchiya

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

QT prolongation on electrocardiography is related to sudden cardiac death and is frequently found in alcoholics. We studied QT prolongation in relation to the function of cardiac autonomic nerves assessed by the coefficient of variation of the R-R interval (CV(RR)) in three age-matched groups of men: 32 alcoholics with autonomic nervous dysfunction (AN), 32 alcoholics without AN, and 32 healthy controls. The QT(C) interval and CV(RR) were measured at rest on the 30th day of abstinence, when electrolyte imbalance had disappeared. Subjects with arrhythmia, conduction abnormality, cardiomegaly, ischemic heart disease or diabetes mellitus were excluded. A CV(RR) of less than 80% of standard predicted value was judged to represent AN. In alcoholics, QT(C) correlated negatively with the ratio of CV(RR) to its standard value (r = - 0.49, p < 0.0001). The incidence of QT(C) prolongation was higher in alcoholics with AN (46.9%) than in alcoholics without AN (21.9%, p < 0.05). QT(C) prolongation was not observed in healthy controls. The QT(C) interval was significantly (p < 0.01) longer in alcoholics with AN (444 ± 20 msec) than in alcoholics without AN (426 ± 17) and in healthy controls (398 ± 18). These results suggest that alcoholism causes dysfunction of the autonomic nerves as well as worsening QT prolongation, and this may predispose such patients to sudden cardiac death.

Original languageEnglish
Pages (from-to)1090-1092
Number of pages3
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number6
DOIs
Publication statusPublished - 1992

Fingerprint

Alcoholics
Medical problems
Electrocardiography
Autonomic Pathways
Electrolytes
Sudden Cardiac Death
Cardiomegaly
Alcoholism
Myocardial Ischemia
Cardiac Arrhythmias
Diabetes Mellitus
Research Design
Age Groups
Incidence

Keywords

  • Alcoholism
  • Autonomic Nervous Dysfunction
  • Heart Rate Variation
  • QT Interval

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Yokoyama, A., Ishii, H., Takagi, T., Hori, S., Matsushita, S., Onishi, S., ... Tsuchiya, M. (1992). Prolonged QT interval in alcoholic autonomic nervous dysfunction. Alcoholism: Clinical and Experimental Research, 16(6), 1090-1092. https://doi.org/10.1111/j.1530-0277.1992.tb00703.x

Prolonged QT interval in alcoholic autonomic nervous dysfunction. / Yokoyama, A.; Ishii, H.; Takagi, T.; Hori, S.; Matsushita, S.; Onishi, S.; Katsukawa, Fuminori; Takei, I.; Kato, Shinzo; Maruyama, K.; Tsuchiya, M.

In: Alcoholism: Clinical and Experimental Research, Vol. 16, No. 6, 1992, p. 1090-1092.

Research output: Contribution to journalArticle

Yokoyama, A, Ishii, H, Takagi, T, Hori, S, Matsushita, S, Onishi, S, Katsukawa, F, Takei, I, Kato, S, Maruyama, K & Tsuchiya, M 1992, 'Prolonged QT interval in alcoholic autonomic nervous dysfunction', Alcoholism: Clinical and Experimental Research, vol. 16, no. 6, pp. 1090-1092. https://doi.org/10.1111/j.1530-0277.1992.tb00703.x
Yokoyama, A. ; Ishii, H. ; Takagi, T. ; Hori, S. ; Matsushita, S. ; Onishi, S. ; Katsukawa, Fuminori ; Takei, I. ; Kato, Shinzo ; Maruyama, K. ; Tsuchiya, M. / Prolonged QT interval in alcoholic autonomic nervous dysfunction. In: Alcoholism: Clinical and Experimental Research. 1992 ; Vol. 16, No. 6. pp. 1090-1092.
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AU - Onishi, S.

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AU - Tsuchiya, M.

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AB - QT prolongation on electrocardiography is related to sudden cardiac death and is frequently found in alcoholics. We studied QT prolongation in relation to the function of cardiac autonomic nerves assessed by the coefficient of variation of the R-R interval (CV(RR)) in three age-matched groups of men: 32 alcoholics with autonomic nervous dysfunction (AN), 32 alcoholics without AN, and 32 healthy controls. The QT(C) interval and CV(RR) were measured at rest on the 30th day of abstinence, when electrolyte imbalance had disappeared. Subjects with arrhythmia, conduction abnormality, cardiomegaly, ischemic heart disease or diabetes mellitus were excluded. A CV(RR) of less than 80% of standard predicted value was judged to represent AN. In alcoholics, QT(C) correlated negatively with the ratio of CV(RR) to its standard value (r = - 0.49, p < 0.0001). The incidence of QT(C) prolongation was higher in alcoholics with AN (46.9%) than in alcoholics without AN (21.9%, p < 0.05). QT(C) prolongation was not observed in healthy controls. The QT(C) interval was significantly (p < 0.01) longer in alcoholics with AN (444 ± 20 msec) than in alcoholics without AN (426 ± 17) and in healthy controls (398 ± 18). These results suggest that alcoholism causes dysfunction of the autonomic nerves as well as worsening QT prolongation, and this may predispose such patients to sudden cardiac death.

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