Prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation: Associations with impaired platelet production and increased platelet turnover

Rie Yamazaki, M. Kuwana, Takehiko Mori, Y. Okazaki, Yutaka Kawakami, Y. Ikeda, Shinichiro Okamoto

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To evaluate the mechanisms underlying prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation (SCT), an index for plasma glycocalicin normalized for the individual platelet count (GCI), plasma thrombopoietin (TPO), and circulating B cells producing anti-GPIIb-IIIa antibodies were measured in 50 SCT recipients with or without prolonged thrombocytopenia, 42 patients with idiopathic thrombocytopenic purpura, nine patients with aplastic anemia, and 22 healthy individuals. All three indices were significantly higher in the SCT recipients with thrombocytopenia than in those without (P<0.01 for all comparisons), and were significantly correlated with the platelet count in SCT recipients. Stepwise multiple regression analysis of the samples from the SCT recipients revealed that GCI and TPO independently pointed to specific mechanisms of thrombocytopenia. The GCI and TPO status in SCT recipients with thrombocytopenia had a pattern similar to that seen in aplastic anemia, suggesting a major role for impaired thrombopoiesis. An antiplatelet antibody response was frequently detected in SCT recipients, but the development of thrombocytopenia is likely to depend on additional factors, such as reticuloendothelial function. In summary, post transplant prolonged thrombocytopenia is associated with complex mechanisms, including impaired thrombopoiesis and increased platelet turnover.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalBone Marrow Transplantation
Volume38
Issue number5
DOIs
Publication statusPublished - 2006 Sep

Fingerprint

Hematopoietic Stem Cell Transplantation
Thrombocytopenia
Stem Cell Transplantation
Blood Platelets
Thrombopoietin
Thrombopoiesis
Aplastic Anemia
Platelet Count
Idiopathic Thrombocytopenic Purpura
Antibody Formation
B-Lymphocytes
Regression Analysis
Transplants
Antibodies

Keywords

  • ITP
  • Platelet antibodies
  • Platelet turnover
  • Stem cell transplantation
  • Thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

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title = "Prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation: Associations with impaired platelet production and increased platelet turnover",
abstract = "To evaluate the mechanisms underlying prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation (SCT), an index for plasma glycocalicin normalized for the individual platelet count (GCI), plasma thrombopoietin (TPO), and circulating B cells producing anti-GPIIb-IIIa antibodies were measured in 50 SCT recipients with or without prolonged thrombocytopenia, 42 patients with idiopathic thrombocytopenic purpura, nine patients with aplastic anemia, and 22 healthy individuals. All three indices were significantly higher in the SCT recipients with thrombocytopenia than in those without (P<0.01 for all comparisons), and were significantly correlated with the platelet count in SCT recipients. Stepwise multiple regression analysis of the samples from the SCT recipients revealed that GCI and TPO independently pointed to specific mechanisms of thrombocytopenia. The GCI and TPO status in SCT recipients with thrombocytopenia had a pattern similar to that seen in aplastic anemia, suggesting a major role for impaired thrombopoiesis. An antiplatelet antibody response was frequently detected in SCT recipients, but the development of thrombocytopenia is likely to depend on additional factors, such as reticuloendothelial function. In summary, post transplant prolonged thrombocytopenia is associated with complex mechanisms, including impaired thrombopoiesis and increased platelet turnover.",
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T1 - Prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation

T2 - Associations with impaired platelet production and increased platelet turnover

AU - Yamazaki, Rie

AU - Kuwana, M.

AU - Mori, Takehiko

AU - Okazaki, Y.

AU - Kawakami, Yutaka

AU - Ikeda, Y.

AU - Okamoto, Shinichiro

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