Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)

K. Matsushige, P. Basnet, Kouji Hase, S. Kadota, K. Tanaka, T. Namba

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 ß(IL-I ß) generation from human leukocytes. The free radical scavenging activity to-gether with IL-I ßand nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalPhytomedicine
Volume3
Issue number2
Publication statusPublished - 1996 Sep
Externally publishedYes

Fingerprint

Propolis
propolis
streptozotocin
Streptozocin
Toxicity
cytotoxicity
protective effect
interleukin-1
toxicity
Interleukin-1
beehives
nicotinamide
Niacinamide
Glues
Scavenging
Urticaria
heart diseases
Medical problems
nitric oxide synthase
Nitric Oxide Synthase

Keywords

  • Free radical scavenger
  • Interleukin-1 β
  • Nitric oxide
  • Propolis
  • Streptozotocin

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Matsushige, K., Basnet, P., Hase, K., Kadota, S., Tanaka, K., & Namba, T. (1996). Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ). Phytomedicine, 3(2), 203-209.

Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ). / Matsushige, K.; Basnet, P.; Hase, Kouji; Kadota, S.; Tanaka, K.; Namba, T.

In: Phytomedicine, Vol. 3, No. 2, 09.1996, p. 203-209.

Research output: Contribution to journalArticle

Matsushige, K, Basnet, P, Hase, K, Kadota, S, Tanaka, K & Namba, T 1996, 'Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)', Phytomedicine, vol. 3, no. 2, pp. 203-209.
Matsushige K, Basnet P, Hase K, Kadota S, Tanaka K, Namba T. Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ). Phytomedicine. 1996 Sep;3(2):203-209.
Matsushige, K. ; Basnet, P. ; Hase, Kouji ; Kadota, S. ; Tanaka, K. ; Namba, T. / Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ). In: Phytomedicine. 1996 ; Vol. 3, No. 2. pp. 203-209.
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