Proposal of histological criteria for intraepithelial atypical/ proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: Preliminary report based on interobserver agreement

Yoh Zen, Shinichi Aishima, Yoichi Ajioka, Joji Haratake, Masayoshi Kage, Fukuo Kondo, Yuji Nimura, Michiie Sakamoto, Motoko Sasaki, Kazuhide Shimamatsu, Kenichi Wakasa, Young Nyun Park, Ming F. Chen, Yutaka Atomi, Yasuni Nakanuma

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Biliary lining epithelia of the bile ducts in biliary diseases are known to have intraepithelial atypical/proliferative lesions related to the development of cholangiocarcinoma. The purpose of the present study was to determine the histological criteria for these lesions based on interobserver agreement. Digital images of 30 intraepithelial atypical/proliferative lesions in the stone-containing intrahepatic bile ducts of hepatolithiasis (30 cases) were sent to 10 pathologists. At first, 10 pathologists made a diagnosis (either of reactive/regenerative change, low-grade or high-grade biliary intraepithelial neoplasia (BillN-1 and BillN-2), or in situ carcinoma (BillN-3)) based on their own criteria. The histological criteria for these four lesions were then determined, and the digital images of the same lesions with proposed criteria were re-distributed. Interobserver agreement on these four lesions was slightly improved (κ = 0.44, first diagnosis; 0.49, second diagnosis) and intraobserver agreement was 'almost perfect' (κ = 0.82 at both first and second diagnosis). Interobserver agreement between BillN-1 and BillN-2 and that between BillN-2 and BillN-3 were 'moderate', although the agreement between regenerative/ reactive change and BillN-1 was 'fair'. In this report, we propose histological criteria for reactive/regenerative change, BillN-1, BillN-2 and BillN-3. Improvement of interobserver agreement suggests their applicability in diagnostic and research fields.

Original languageEnglish
Pages (from-to)180-188
Number of pages9
JournalPathology international
Volume55
Issue number4
DOIs
Publication statusPublished - 2005 Apr

Keywords

  • Biliary intraepithelial neoplasia
  • Dysplasia-carcinoma sequence
  • Intraductal papillary mucinous neoplasm
  • Intrahepatic bile duct
  • Intrahepatic cholangiocarcinoma
  • Premalignant lesion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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