Proposal of new clinical diagnostic criteria for POEMS syndrome

Tomoki Suichi, Sonoko Misawa, Yasunori Sato, Minako Beppu, Emiko Sakaida, Yukari Sekiguchi, Kazumoto Shibuya, Keisuke Watanabe, Hiroshi Amino, Satoshi Kuwabara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective To propose the optimal diagnostic criteria for polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome using appropriate statistical methods and disease controls. Methods This retrospective cohort study included 104 consecutive patients with suspected POEMS syndrome, among whom a gold standard group of 60 patients with definitive POEMS syndrome diagnosis were followed for at least 12 months to strictly exclude other disorders mimicking POEMS syndrome and to confirm response to POEMS syndrome-specific treatment. Thirty patients with chronic inflammatory demyelinating polyradiculoneuropathy (demyelinating polyradiculoneuropathy controls) and 30 with multiple myeloma or immunoglobulin light chain amyloidosis (monoclonal plasma cell proliferation controls) were also included. Logistic regression analyses were performed to determine optimal combination of clinical and laboratory abnormalities, characteristic of POEMS syndrome. Results The diagnostic criteria were statistically defined as the presence of the three major criteria (polyneuropathy (typically demyelinating), monoclonal plasma cell proliferative disorder and elevated vascular endothelial growth factor) and at least two of the four minor criteria (oedema/effusion, skin changes, organomegaly and sclerotic bone lesions), based on best performance by area under the receiver operating characteristic curve analyses. The sensitivity and specificity were 100% and 100%, respectively; the diagnostic accuracy of the proposed criteria was equivalent to somewhat complicated previous criteria. Conclusions The statistically defined, simple diagnostic criteria for POEMS syndrome could accelerate early diagnosis and treatment, thereby contribute to better outcome in patients with this serious disease. Prospective larger studies are required to confirm the validity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume90
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1
Externally publishedYes

Fingerprint

POEMS Syndrome
Plasma Cells
Polyradiculoneuropathy
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Immunoglobulin Light Chains
Polyneuropathies
Amyloidosis
Multiple Myeloma
ROC Curve
Vascular Endothelial Growth Factor A
Early Diagnosis
Edema
Cohort Studies
Retrospective Studies
Logistic Models
Regression Analysis
Cell Proliferation
Prospective Studies
Bone and Bones
Sensitivity and Specificity

Keywords

  • diagnostic criteria
  • POEMS syndrome
  • sensitivity
  • specificity

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Suichi, T., Misawa, S., Sato, Y., Beppu, M., Sakaida, E., Sekiguchi, Y., ... Kuwabara, S. (2019). Proposal of new clinical diagnostic criteria for POEMS syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 90(2), 133-137. https://doi.org/10.1136/jnnp-2018-318514

Proposal of new clinical diagnostic criteria for POEMS syndrome. / Suichi, Tomoki; Misawa, Sonoko; Sato, Yasunori; Beppu, Minako; Sakaida, Emiko; Sekiguchi, Yukari; Shibuya, Kazumoto; Watanabe, Keisuke; Amino, Hiroshi; Kuwabara, Satoshi.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 90, No. 2, 01.02.2019, p. 133-137.

Research output: Contribution to journalArticle

Suichi, T, Misawa, S, Sato, Y, Beppu, M, Sakaida, E, Sekiguchi, Y, Shibuya, K, Watanabe, K, Amino, H & Kuwabara, S 2019, 'Proposal of new clinical diagnostic criteria for POEMS syndrome', Journal of Neurology, Neurosurgery and Psychiatry, vol. 90, no. 2, pp. 133-137. https://doi.org/10.1136/jnnp-2018-318514
Suichi, Tomoki ; Misawa, Sonoko ; Sato, Yasunori ; Beppu, Minako ; Sakaida, Emiko ; Sekiguchi, Yukari ; Shibuya, Kazumoto ; Watanabe, Keisuke ; Amino, Hiroshi ; Kuwabara, Satoshi. / Proposal of new clinical diagnostic criteria for POEMS syndrome. In: Journal of Neurology, Neurosurgery and Psychiatry. 2019 ; Vol. 90, No. 2. pp. 133-137.
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