Proprotein convertase subtilisin/kexin type 9 is associated with degenerating adipocytes in abdominal aortic aneurysm

Hiroki Tanaka, Kazunori Inuzuka, Yasunori Iida, Hideyuki Shimizu, Naoki Unno, Tetsumei Urano

Research output: Contribution to journalArticle

Abstract

Abdominal aortic aneurysm (AAA) is a common disease among the elderly. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been indicated as useful therapeutic tools for the treatment of cardiovascular diseases. The aim of this study was to elucidate the role of PCSK9 in the pathogenesis of AAA. We used fluorescence immunohistochemistry to assess the expression of PCSK9 in aortic tissues resected from 24 patients with AAA. Histological examination showed that PCSK9 expression in the adventitia region of the aneurysms was decreased in AAA samples. In the same region, the expression of CD36 increased. We hypothesized that CD36 expression might upregulate the transport of fatty acids into cells such as the adipocytes, and subsequently cause degradation of the adventitia in the aortic wall, contributing to AAA development.

Original languageEnglish
Pages (from-to)1355-1360
Number of pages6
JournalJournal of Oleo Science
Volume67
Issue number10
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Proprotein Convertases
Subtilisin
Fatty acids
Fluorescence
Tissue
Degradation
Fatty Acids
Immunohistochemistry

Keywords

  • Abdominal aortic aneurysm
  • Adipocyte
  • CD36
  • PCSK9

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Proprotein convertase subtilisin/kexin type 9 is associated with degenerating adipocytes in abdominal aortic aneurysm. / Tanaka, Hiroki; Inuzuka, Kazunori; Iida, Yasunori; Shimizu, Hideyuki; Unno, Naoki; Urano, Tetsumei.

In: Journal of Oleo Science, Vol. 67, No. 10, 01.01.2018, p. 1355-1360.

Research output: Contribution to journalArticle

Tanaka, Hiroki ; Inuzuka, Kazunori ; Iida, Yasunori ; Shimizu, Hideyuki ; Unno, Naoki ; Urano, Tetsumei. / Proprotein convertase subtilisin/kexin type 9 is associated with degenerating adipocytes in abdominal aortic aneurysm. In: Journal of Oleo Science. 2018 ; Vol. 67, No. 10. pp. 1355-1360.
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