(Pro)renin receptor: Pathological role and therapeutic potential in primary hypertension

Kanako Bokuda, Atsuhiro Ichihara, Hiroshi Itoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Renin-angiotensin system (RAS) is known to be a regulator of blood pressure, volume homeostasis, and cardiovascular growth and remodeling, but is still incompletely understood. Tissue RAS plays important roles in development of target-organ damages in pathological states such as hypertension and diabetes. The pathophysiological roles of (pro)renin receptor [(P)RR] have been growing concern. (P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin and the intracellular signalings. In this article, we attempt to elucidate the possible pathophysiological roles of the (P)RR and the therapeutic potential in primary hypertension, through reviewing studies on animal models of hypertension, transgenic rats overexpressing (P)RR and genetic analysis in humans.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalCurrent Hypertension Reviews
Volume8
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Renin
Hypertension
Renin-Angiotensin System
Transgenic Rats
Therapeutics
Blood Volume
Homeostasis
Animal Models
Blood Pressure
Growth

Keywords

  • Blood pressure
  • Handle region peptide
  • Intracellular signaling
  • Nonproteolytic activation
  • Polymorphism
  • Renin-angiotensin system
  • Target-organ damage
  • Vacuolar H - ATPase

ASJC Scopus subject areas

  • Internal Medicine

Cite this

(Pro)renin receptor : Pathological role and therapeutic potential in primary hypertension. / Bokuda, Kanako; Ichihara, Atsuhiro; Itoh, Hiroshi.

In: Current Hypertension Reviews, Vol. 8, No. 1, 2012, p. 9-14.

Research output: Contribution to journalArticle

@article{30b97cc9b51e4db3a2195415cb27d075,
title = "(Pro)renin receptor: Pathological role and therapeutic potential in primary hypertension",
abstract = "Renin-angiotensin system (RAS) is known to be a regulator of blood pressure, volume homeostasis, and cardiovascular growth and remodeling, but is still incompletely understood. Tissue RAS plays important roles in development of target-organ damages in pathological states such as hypertension and diabetes. The pathophysiological roles of (pro)renin receptor [(P)RR] have been growing concern. (P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin and the intracellular signalings. In this article, we attempt to elucidate the possible pathophysiological roles of the (P)RR and the therapeutic potential in primary hypertension, through reviewing studies on animal models of hypertension, transgenic rats overexpressing (P)RR and genetic analysis in humans.",
keywords = "Blood pressure, Handle region peptide, Intracellular signaling, Nonproteolytic activation, Polymorphism, Renin-angiotensin system, Target-organ damage, Vacuolar H - ATPase",
author = "Kanako Bokuda and Atsuhiro Ichihara and Hiroshi Itoh",
year = "2012",
doi = "10.2174/157340212800504963",
language = "English",
volume = "8",
pages = "9--14",
journal = "Current Medical Imaging Reviews",
issn = "1573-4056",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - (Pro)renin receptor

T2 - Pathological role and therapeutic potential in primary hypertension

AU - Bokuda, Kanako

AU - Ichihara, Atsuhiro

AU - Itoh, Hiroshi

PY - 2012

Y1 - 2012

N2 - Renin-angiotensin system (RAS) is known to be a regulator of blood pressure, volume homeostasis, and cardiovascular growth and remodeling, but is still incompletely understood. Tissue RAS plays important roles in development of target-organ damages in pathological states such as hypertension and diabetes. The pathophysiological roles of (pro)renin receptor [(P)RR] have been growing concern. (P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin and the intracellular signalings. In this article, we attempt to elucidate the possible pathophysiological roles of the (P)RR and the therapeutic potential in primary hypertension, through reviewing studies on animal models of hypertension, transgenic rats overexpressing (P)RR and genetic analysis in humans.

AB - Renin-angiotensin system (RAS) is known to be a regulator of blood pressure, volume homeostasis, and cardiovascular growth and remodeling, but is still incompletely understood. Tissue RAS plays important roles in development of target-organ damages in pathological states such as hypertension and diabetes. The pathophysiological roles of (pro)renin receptor [(P)RR] have been growing concern. (P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin and the intracellular signalings. In this article, we attempt to elucidate the possible pathophysiological roles of the (P)RR and the therapeutic potential in primary hypertension, through reviewing studies on animal models of hypertension, transgenic rats overexpressing (P)RR and genetic analysis in humans.

KW - Blood pressure

KW - Handle region peptide

KW - Intracellular signaling

KW - Nonproteolytic activation

KW - Polymorphism

KW - Renin-angiotensin system

KW - Target-organ damage

KW - Vacuolar H - ATPase

UR - http://www.scopus.com/inward/record.url?scp=84870178920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870178920&partnerID=8YFLogxK

U2 - 10.2174/157340212800504963

DO - 10.2174/157340212800504963

M3 - Article

AN - SCOPUS:84870178920

VL - 8

SP - 9

EP - 14

JO - Current Medical Imaging Reviews

JF - Current Medical Imaging Reviews

SN - 1573-4056

IS - 1

ER -