(Pro)renin receptor: Pathological role and therapeutic potential in primary hypertension

Kanako Bokuda, Atsuhiro Ichihara, Hiroshi Itoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Renin-angiotensin system (RAS) is known to be a regulator of blood pressure, volume homeostasis, and cardiovascular growth and remodeling, but is still incompletely understood. Tissue RAS plays important roles in development of target-organ damages in pathological states such as hypertension and diabetes. The pathophysiological roles of (pro)renin receptor [(P)RR] have been growing concern. (P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin and the intracellular signalings. In this article, we attempt to elucidate the possible pathophysiological roles of the (P)RR and the therapeutic potential in primary hypertension, through reviewing studies on animal models of hypertension, transgenic rats overexpressing (P)RR and genetic analysis in humans.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalCurrent Hypertension Reviews
Volume8
Issue number1
DOIs
Publication statusPublished - 2012

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Keywords

  • Blood pressure
  • Handle region peptide
  • Intracellular signaling
  • Nonproteolytic activation
  • Polymorphism
  • Renin-angiotensin system
  • Target-organ damage
  • Vacuolar H - ATPase

ASJC Scopus subject areas

  • Internal Medicine

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