Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis

Tomohisa Sakaue, Masashi Maekawa, Hironao Nakayama, Shigeki Higashiyama

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Tissue remodelling and regeneration in various pathophysiological conditions (e.g. the processes of development, pregnancy, inflammation, wound healing, tissue regeneration, tumor growth, etc.) require angiogenesis, a dynamically coordinated response to stimuli from the extracellular microenvironment. During angiogenic and angiostatic responses, endothelial cells play a central role in the blood vessel formation and regression. Angiostatic responses, which are evoked by crucial factors such as VEGF and DLL4, have been elucidated. However, it has not been revealed, how endothelial cells process these conflicting signals. The study of VEGFR-Notch cross-signalling provided some clues. We discuss here the potential roles of cullin 3-based ubiquitin E3 ligases as key players in the process of various signals in endothelial cell function and angiogenesis. Our recent findings show that they function as units to process conflicting signalling crosstalk, epigenetic regulation of key factors, and functional barrier maintenance. We also expect more divergent roles of cullin 3-based ubiquitin E3 ligases in endothelial cell function and angiogenesis, and for their potential use as therapeutic targets.

Original languageEnglish
Pages (from-to)237-245
Number of pages9
JournalJournal of biochemistry
Volume162
Issue number4
DOIs
Publication statusPublished - 2017 Oct 1
Externally publishedYes

Keywords

  • angiogenesis
  • BTBP
  • CUL3
  • endothelial cell
  • ubiquitin ligase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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