Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps

Toshio Uraoka, Reiji Higashi, Joichiro Horii, Keita Harada, Keisuke Hori, Hiroyuki Okada, Motowo Mizuno, Jun Tomoda, Nobuya Ohara, Takehiro Tanaka, Han Mo Chiu, Naohisa Yahagi, Kazuhide Yamamoto

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23 Citations (Scopus)

Abstract

Background: Differentiating sessile serrated adenoma/polyp (SSA/P) from hyperplastic polyp (HP) is clinically important in determining the necessity of endoscopic resection or recommending appropriate surveillance. There are few reports of characterization of SSA/P using narrowband imaging and chromoendoscopy with and without magnification. We aimed to establish imaging criteria to aid real-time diagnosis of SSA/P. Methods: Patients with pale sessile or flat lesions of 6 mm or greater were prospectively enrolled in this multicenter trial. Nine endoscopic criteria, determined in real time, were investigated for possible association with SSA/P. Endoscopic mucosal resection was performed; specimens were retrieved and analyzed by histopathological examination. Results: In 63 patients, 89 lesions were detected, including 41 HP, 38 SSA/P, five mixed polyps, and five other lesions. Right-side colon location, lesion size of 10 mm or greater, excessive mucus, the presence of a varicose microvascular vessel (VMV) noted with high-magnification narrowband imaging, and type IIIH pit pattern were each commonly associated with SSA/P compared with HP. Multivariate analysis substantiated three independent endoscopic criteria for SSA/P: the presence of VMV (p = 0.001), lesion size of 10 mm or greater (p = 0.0017), and right-side location (p = 0.0041), with odds ratios of 8.2, 7.2, and 6.1, respectively. The presence of VMV had a significantly higher specificity (87.8 %) than the other two independent endoscopic criteria (p = 0.0007 and p = 0.0008, respectively), but a lower sensitivity (57.9 %), whereas a combination of the three criteria (two or more positive) increased the sensitivity significantly (89.5 % and p = 0.0033) and had a higher degree of accuracy (82.3 %). Conclusions: Three endoscopic criteria individually and in combination were effective in predicting a diagnosis of SSA/P without the need for chromoendoscopy.

Original languageEnglish
Pages (from-to)555-563
Number of pages9
JournalJournal of gastroenterology
Volume50
Issue number5
DOIs
Publication statusPublished - 2015 May 1

Keywords

  • Colonoscopy
  • Magnification endoscopy
  • Narrowband imaging
  • Pit pattern
  • Sessile serrated adenoma/polyp
  • Varicose microvascular vessel

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Uraoka, T., Higashi, R., Horii, J., Harada, K., Hori, K., Okada, H., Mizuno, M., Tomoda, J., Ohara, N., Tanaka, T., Chiu, H. M., Yahagi, N., & Yamamoto, K. (2015). Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps. Journal of gastroenterology, 50(5), 555-563. https://doi.org/10.1007/s00535-014-0999-y