Prospective survey of erectile dysfunction after external beam radiotherapy for prostate cancer

Eiji Kikuchi, Jun Nakashima, Toshiyuki Ando, Hirohiko Nagata, Akira Miyajima, Ken Nakagawa, Ken Marumo, Mototsugu Oya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

(Objective) We prospectively evaluated the effect of external beam radiotherapy on erectile function in patients with localized or locally advanced prostate cancer using the Japanese version of the International Index of Erectile Function (IIEF) survey. (Patients and methods) From 2000 to 2007, we identified 55 patients who underwent external beam radiotherapy at our institution for localized or locally advanced prostate cancer and could respond to the IIEF survey. The patients did not receive neo- and/or adjuvant hormone therapy and they were followed-up for at least 12 months after radiotherapy. Mean patient age was 69 years and the mean PSA level before radiotherapy was 24.9 ng/ml. (Results) First we evaluated the change of the erectile function domain score over time before and after radiotherapy. The population of severe erectile dysfunction (ED) increased while those with no or mild ED decreased after radiotherapy. The erectile function and intercourse satisfaction domain score of the IIEF declined significantly after radiotherapy, however, the orgasmic function, sexual desire, and overall satisfaction domain scores did not change after external beam radiation. Of the 34 patients who had erectile function at baseline, 10 patients could maintain erectile function 12 months after radiotherapy. Though there were no significant differences in clinical features between patients who could maintain erectile function and those who had worsening erectile function 12 months after radiotherapy, the sexual desire domain score before radiotherapy was significantly higher in patients who could maintain erectile function than their counterparts. (Conclusion) Using the IIEF survey, external beam radiation was found to affect erectile function in patients with localized or locally advanced prostate cancer.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalJapanese Journal of Urology
Volume102
Issue number3
Publication statusPublished - 2011 May

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Erectile Dysfunction
Prostatic Neoplasms
Radiotherapy
Surveys and Questionnaires
Radiation
Hormones

Keywords

  • Erectile dysfunction
  • External beam radiation
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Kikuchi, E., Nakashima, J., Ando, T., Nagata, H., Miyajima, A., Nakagawa, K., ... Oya, M. (2011). Prospective survey of erectile dysfunction after external beam radiotherapy for prostate cancer. Japanese Journal of Urology, 102(3), 575-580.

Prospective survey of erectile dysfunction after external beam radiotherapy for prostate cancer. / Kikuchi, Eiji; Nakashima, Jun; Ando, Toshiyuki; Nagata, Hirohiko; Miyajima, Akira; Nakagawa, Ken; Marumo, Ken; Oya, Mototsugu.

In: Japanese Journal of Urology, Vol. 102, No. 3, 05.2011, p. 575-580.

Research output: Contribution to journalArticle

Kikuchi, E, Nakashima, J, Ando, T, Nagata, H, Miyajima, A, Nakagawa, K, Marumo, K & Oya, M 2011, 'Prospective survey of erectile dysfunction after external beam radiotherapy for prostate cancer', Japanese Journal of Urology, vol. 102, no. 3, pp. 575-580.
Kikuchi E, Nakashima J, Ando T, Nagata H, Miyajima A, Nakagawa K et al. Prospective survey of erectile dysfunction after external beam radiotherapy for prostate cancer. Japanese Journal of Urology. 2011 May;102(3):575-580.
Kikuchi, Eiji ; Nakashima, Jun ; Ando, Toshiyuki ; Nagata, Hirohiko ; Miyajima, Akira ; Nakagawa, Ken ; Marumo, Ken ; Oya, Mototsugu. / Prospective survey of erectile dysfunction after external beam radiotherapy for prostate cancer. In: Japanese Journal of Urology. 2011 ; Vol. 102, No. 3. pp. 575-580.
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