Prostate cancer screening strategies with re-screening interval determined by individual baseline prostate-specific antigen values are cost-effective

T. Kobayashi, Rei Goto, K. Ito, K. Mitsumori

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aims: To determine whether prostate cancer screening strategies with re-screening interval determined by individual baseline prostate-specific antigen values are cost-effective. Methods: Based on the results of an actual contemporary screening program, we established Markov decision analytic models of prostate cancer screening with personalized re-screening interval strategies using cutoff baseline PSA levels for biennial screening as well as a model of uniformly annual or biennial screening. These strategies were compared in terms of cumulative incidence of early cancer and cost-effectiveness. Results: Early cancer detection rates were similar among all strategies. Personalized strategies were more cost-effective compared to uniform screening strategies. If all participants with negative PSA results uniformly omit annual screening, it would be more costly but less effective (dominated). Contrary, annual screening for all participants would cost too much. These results were robust throughout sensitivity analysis incorporating every assumption in the models. Conclusions: This study adds important evidence that personalized rescreening strategies based on individual baseline PSA have advantages of cost-effectiveness against conventional uniform strategies.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume33
Issue number6
DOIs
Publication statusPublished - 2007 Aug
Externally publishedYes

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Keywords

  • Cost-effectiveness
  • Decision-analytic model
  • Mass screening
  • Prostate neoplasms
  • Prostate-specific antigen (PSA)

ASJC Scopus subject areas

  • Oncology
  • Surgery

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