Protean manifestations of lipoid proteinosis in a 16-year-old boy

T. Nagasaka, M. Tanaka, D. Ito, K. Tanaka, H. Shimizu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We report a 16-year-old Japanese male with lipoid proteinosis showing various skin manifestations. The patient was born to nonconsanguineous parents and none of his relatives was similarly affected. The patient suffered from a hoarse voice and refractory temporal epilepsy from early childhood. Computed tomography scanning of the brain showed bilateral calcification in the temporal lobes, a characteristic feature of lipoid proteinosis. On physical examination, various skin manifestations, including papules and haemorrhagic blisters, acne-like scars at sites of minor trauma or friction, and beads of small papules along the free margins of the eyelids were noted. A skin biopsy showed deposits of homogenous hyaline-like material, positive on periodic acid-Schiff staining throughout the dermis, particularly around small blood vessels. It is noteworthy that a range of characteristic skin lesions can be present in a patient with lipoid proteinosis even with mild systemic involvement.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalClinical and Experimental Dermatology
Volume25
Issue number1
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Dermatology

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