Protean manifestations of lipoid proteinosis in a 16-year-old boy

T. Nagasaka, M. Tanaka, Daisuke Ito, K. Tanaka, H. Shimizu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We report a 16-year-old Japanese male with lipoid proteinosis showing various skin manifestations. The patient was born to nonconsanguineous parents and none of his relatives was similarly affected. The patient suffered from a hoarse voice and refractory temporal epilepsy from early childhood. Computed tomography scanning of the brain showed bilateral calcification in the temporal lobes, a characteristic feature of lipoid proteinosis. On physical examination, various skin manifestations, including papules and haemorrhagic blisters, acne-like scars at sites of minor trauma or friction, and beads of small papules along the free margins of the eyelids were noted. A skin biopsy showed deposits of homogenous hyaline-like material, positive on periodic acid-Schiff staining throughout the dermis, particularly around small blood vessels. It is noteworthy that a range of characteristic skin lesions can be present in a patient with lipoid proteinosis even with mild systemic involvement.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalClinical and Experimental Dermatology
Volume25
Issue number1
DOIs
Publication statusPublished - 2000

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Skin Manifestations
Skin
Periodic Acid
Hyalin
Friction
Acne Vulgaris
Eyelids
Temporal Lobe
Blister
Dermis
Physical Examination
Cicatrix
Blood Vessels
Epilepsy
Parents
Tomography
Staining and Labeling
Biopsy
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Dermatology

Cite this

Protean manifestations of lipoid proteinosis in a 16-year-old boy. / Nagasaka, T.; Tanaka, M.; Ito, Daisuke; Tanaka, K.; Shimizu, H.

In: Clinical and Experimental Dermatology, Vol. 25, No. 1, 2000, p. 30-32.

Research output: Contribution to journalArticle

Nagasaka, T. ; Tanaka, M. ; Ito, Daisuke ; Tanaka, K. ; Shimizu, H. / Protean manifestations of lipoid proteinosis in a 16-year-old boy. In: Clinical and Experimental Dermatology. 2000 ; Vol. 25, No. 1. pp. 30-32.
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