Protection of ischemic myocardium by inhibition of contracture in isolated rat heart

M. Tani, H. Hasegawa, Y. Suganuma, K. Shinmura, Y. Kayashi, Y. Nakamura

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Protection of the ischemic myocardium by pretreatment with a high dose of 2,3-butanedione monoxime (BDM) is attributed to the enhancement of glycolytic ATP production rather than to the inhibition of contracture during mild ischemia. Our objective was to investigate whether the inhibition of contracture would protect the arrested heart during prolonged ischemia. Isolated perfused rat hearts were subjected to 30 min of low-flow ischemia followed by reperfusion. Ischemic hearts were treated with BDM (5 mmol/l) after beating stopped. BDM ameliorated the increase in intraventricular pressure after ischemia without significant changes in ATP levels and with a decreased accumulation of lactate. BDM treatment accelerated the recovery of function and high-energy phosphates with reduced myocardial Ca2+ overload. The results of this study suggested that inhibition of contracture can protect the heart from ischemia-reperfusion injury.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume271
Issue number6 40-6
Publication statusPublished - 1996

Fingerprint

Contracture
Myocardium
Ischemia
Adenosine Triphosphate
Recovery of Function
Ventricular Pressure
Reperfusion Injury
Reperfusion
Lactic Acid
Phosphates
diacetylmonoxime

Keywords

  • 2,3-butanedione monoxime
  • energy-sparing effect
  • negative inotropic effect

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Tani, M., Hasegawa, H., Suganuma, Y., Shinmura, K., Kayashi, Y., & Nakamura, Y. (1996). Protection of ischemic myocardium by inhibition of contracture in isolated rat heart. American Journal of Physiology - Heart and Circulatory Physiology, 271(6 40-6).

Protection of ischemic myocardium by inhibition of contracture in isolated rat heart. / Tani, M.; Hasegawa, H.; Suganuma, Y.; Shinmura, K.; Kayashi, Y.; Nakamura, Y.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 271, No. 6 40-6, 1996.

Research output: Contribution to journalArticle

Tani, M, Hasegawa, H, Suganuma, Y, Shinmura, K, Kayashi, Y & Nakamura, Y 1996, 'Protection of ischemic myocardium by inhibition of contracture in isolated rat heart', American Journal of Physiology - Heart and Circulatory Physiology, vol. 271, no. 6 40-6.
Tani, M. ; Hasegawa, H. ; Suganuma, Y. ; Shinmura, K. ; Kayashi, Y. ; Nakamura, Y. / Protection of ischemic myocardium by inhibition of contracture in isolated rat heart. In: American Journal of Physiology - Heart and Circulatory Physiology. 1996 ; Vol. 271, No. 6 40-6.
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