Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation

Yoshinobu Kanda, Hidenori Wada, Ryoko Yamasaki, Koji Kawamura, Yuko Ishihara, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Tomohito Machishima, Kiriko Terasako-Saito, Shun Ichi Kimura, Hideki Nakasone, Misato Kikuchi, Rie Yamazaki, Junya Kanda, Shinichi Kako, Junji Nishida, Hidekazu Tsunoda, Yoshio Omori, Masanori Nakazawa & 1 others Osamu Tanaka

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To prevent ovarian dysfunction due to total body irradiation, we started ovarian shielding at our center (Saitama Medical Center, Jichi Medical University (SMC-JMU)) with a long source axis distance, which is different from the original method used at the University of Tokyo Hospital (UTH). We retrospectively analyzed the outcome of eight patients with a median age of 20.5 years from SMC-JMU and compared the results with the published data for eight patients with a median age of 22 years from UTH. The recovery of ovarian function was observed in five and six patients, respectively. The cumulative incidence of ovarian recovery, while treating relapse and death without ovarian recovery as competing risks, was 68.8 % at 2 years after transplantation in the total population, and there was no statistically significant difference between the two institutions (p = 0.85). Age and the history of previous chemotherapy did not affect the incidence of ovarian recovery. Two patients from each center had a relapse of leukemia. Overall, among the 11 patients who have survived without relapse, only one has not achieved ovarian recovery. In conclusion, ovarian shielding with both methods strongly protected ovarian function. However, we should continue to monitor the relapse rate among patients who undergo this procedure.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalAnnals of Hematology
Volume93
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1
Externally publishedYes

Fingerprint

Whole-Body Irradiation
Recurrence
Tokyo
Incidence
Recovery of Function
Leukemia
Transplantation
History
Drug Therapy
Population

Keywords

  • Fertility
  • Hematopoietic stem cell transplantation
  • Ovarian function
  • Shielding
  • Total body irradiation

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation. / Kanda, Yoshinobu; Wada, Hidenori; Yamasaki, Ryoko; Kawamura, Koji; Ishihara, Yuko; Sakamoto, Kana; Ashizawa, Masahiro; Sato, Miki; Machishima, Tomohito; Terasako-Saito, Kiriko; Kimura, Shun Ichi; Nakasone, Hideki; Kikuchi, Misato; Yamazaki, Rie; Kanda, Junya; Kako, Shinichi; Nishida, Junji; Tsunoda, Hidekazu; Omori, Yoshio; Nakazawa, Masanori; Tanaka, Osamu.

In: Annals of Hematology, Vol. 93, No. 2, 01.02.2014, p. 287-292.

Research output: Contribution to journalArticle

Kanda, Y, Wada, H, Yamasaki, R, Kawamura, K, Ishihara, Y, Sakamoto, K, Ashizawa, M, Sato, M, Machishima, T, Terasako-Saito, K, Kimura, SI, Nakasone, H, Kikuchi, M, Yamazaki, R, Kanda, J, Kako, S, Nishida, J, Tsunoda, H, Omori, Y, Nakazawa, M & Tanaka, O 2014, 'Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation', Annals of Hematology, vol. 93, no. 2, pp. 287-292. https://doi.org/10.1007/s00277-013-1852-8
Kanda, Yoshinobu ; Wada, Hidenori ; Yamasaki, Ryoko ; Kawamura, Koji ; Ishihara, Yuko ; Sakamoto, Kana ; Ashizawa, Masahiro ; Sato, Miki ; Machishima, Tomohito ; Terasako-Saito, Kiriko ; Kimura, Shun Ichi ; Nakasone, Hideki ; Kikuchi, Misato ; Yamazaki, Rie ; Kanda, Junya ; Kako, Shinichi ; Nishida, Junji ; Tsunoda, Hidekazu ; Omori, Yoshio ; Nakazawa, Masanori ; Tanaka, Osamu. / Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation. In: Annals of Hematology. 2014 ; Vol. 93, No. 2. pp. 287-292.
@article{34e80d378c484139832b0f200379ce7c,
title = "Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation",
abstract = "To prevent ovarian dysfunction due to total body irradiation, we started ovarian shielding at our center (Saitama Medical Center, Jichi Medical University (SMC-JMU)) with a long source axis distance, which is different from the original method used at the University of Tokyo Hospital (UTH). We retrospectively analyzed the outcome of eight patients with a median age of 20.5 years from SMC-JMU and compared the results with the published data for eight patients with a median age of 22 years from UTH. The recovery of ovarian function was observed in five and six patients, respectively. The cumulative incidence of ovarian recovery, while treating relapse and death without ovarian recovery as competing risks, was 68.8 {\%} at 2 years after transplantation in the total population, and there was no statistically significant difference between the two institutions (p = 0.85). Age and the history of previous chemotherapy did not affect the incidence of ovarian recovery. Two patients from each center had a relapse of leukemia. Overall, among the 11 patients who have survived without relapse, only one has not achieved ovarian recovery. In conclusion, ovarian shielding with both methods strongly protected ovarian function. However, we should continue to monitor the relapse rate among patients who undergo this procedure.",
keywords = "Fertility, Hematopoietic stem cell transplantation, Ovarian function, Shielding, Total body irradiation",
author = "Yoshinobu Kanda and Hidenori Wada and Ryoko Yamasaki and Koji Kawamura and Yuko Ishihara and Kana Sakamoto and Masahiro Ashizawa and Miki Sato and Tomohito Machishima and Kiriko Terasako-Saito and Kimura, {Shun Ichi} and Hideki Nakasone and Misato Kikuchi and Rie Yamazaki and Junya Kanda and Shinichi Kako and Junji Nishida and Hidekazu Tsunoda and Yoshio Omori and Masanori Nakazawa and Osamu Tanaka",
year = "2014",
month = "2",
day = "1",
doi = "10.1007/s00277-013-1852-8",
language = "English",
volume = "93",
pages = "287--292",
journal = "Annals of Hematology",
issn = "0939-5555",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation

AU - Kanda, Yoshinobu

AU - Wada, Hidenori

AU - Yamasaki, Ryoko

AU - Kawamura, Koji

AU - Ishihara, Yuko

AU - Sakamoto, Kana

AU - Ashizawa, Masahiro

AU - Sato, Miki

AU - Machishima, Tomohito

AU - Terasako-Saito, Kiriko

AU - Kimura, Shun Ichi

AU - Nakasone, Hideki

AU - Kikuchi, Misato

AU - Yamazaki, Rie

AU - Kanda, Junya

AU - Kako, Shinichi

AU - Nishida, Junji

AU - Tsunoda, Hidekazu

AU - Omori, Yoshio

AU - Nakazawa, Masanori

AU - Tanaka, Osamu

PY - 2014/2/1

Y1 - 2014/2/1

N2 - To prevent ovarian dysfunction due to total body irradiation, we started ovarian shielding at our center (Saitama Medical Center, Jichi Medical University (SMC-JMU)) with a long source axis distance, which is different from the original method used at the University of Tokyo Hospital (UTH). We retrospectively analyzed the outcome of eight patients with a median age of 20.5 years from SMC-JMU and compared the results with the published data for eight patients with a median age of 22 years from UTH. The recovery of ovarian function was observed in five and six patients, respectively. The cumulative incidence of ovarian recovery, while treating relapse and death without ovarian recovery as competing risks, was 68.8 % at 2 years after transplantation in the total population, and there was no statistically significant difference between the two institutions (p = 0.85). Age and the history of previous chemotherapy did not affect the incidence of ovarian recovery. Two patients from each center had a relapse of leukemia. Overall, among the 11 patients who have survived without relapse, only one has not achieved ovarian recovery. In conclusion, ovarian shielding with both methods strongly protected ovarian function. However, we should continue to monitor the relapse rate among patients who undergo this procedure.

AB - To prevent ovarian dysfunction due to total body irradiation, we started ovarian shielding at our center (Saitama Medical Center, Jichi Medical University (SMC-JMU)) with a long source axis distance, which is different from the original method used at the University of Tokyo Hospital (UTH). We retrospectively analyzed the outcome of eight patients with a median age of 20.5 years from SMC-JMU and compared the results with the published data for eight patients with a median age of 22 years from UTH. The recovery of ovarian function was observed in five and six patients, respectively. The cumulative incidence of ovarian recovery, while treating relapse and death without ovarian recovery as competing risks, was 68.8 % at 2 years after transplantation in the total population, and there was no statistically significant difference between the two institutions (p = 0.85). Age and the history of previous chemotherapy did not affect the incidence of ovarian recovery. Two patients from each center had a relapse of leukemia. Overall, among the 11 patients who have survived without relapse, only one has not achieved ovarian recovery. In conclusion, ovarian shielding with both methods strongly protected ovarian function. However, we should continue to monitor the relapse rate among patients who undergo this procedure.

KW - Fertility

KW - Hematopoietic stem cell transplantation

KW - Ovarian function

KW - Shielding

KW - Total body irradiation

UR - http://www.scopus.com/inward/record.url?scp=84895060587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895060587&partnerID=8YFLogxK

U2 - 10.1007/s00277-013-1852-8

DO - 10.1007/s00277-013-1852-8

M3 - Article

VL - 93

SP - 287

EP - 292

JO - Annals of Hematology

JF - Annals of Hematology

SN - 0939-5555

IS - 2

ER -