Protective effect of β-(1,3→1,6)-d-glucan against irritant-induced gastric lesions

Ken Ichiro Tanaka, Yuta Tanaka, Toshio Suzuki, Tohru Mizushima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

β-(1,3)-d-Glucan with β-(1,6) branches has been reported to have various pharmacological activities, such as anti-tumour and anti-infection activities, which result from its immunomodulating effects. Gastric lesions result from an imbalance between aggressive and defensive factors. In the present study, we examined the effect of β-(1,3)-d-glucan with β-(1,6) branches isolated from Aureobasidium pullulans on the gastric ulcerogenic response in mice. Oral administration of β-glucan ameliorated gastric lesions induced by ethanol (EtOH) or HCl. This administration of β-glucan also suppressed EtOH-induced inflammatory responses, such as infiltration of neutrophils and expression of pro-inflammatory cytokines, chemokines and cell adhesion molecules (CAM) at the gastric mucosa. Of the various defensive factors, the levels of heat shock protein (HSP) 70 and mucin but not PGE2 were increased by the administration of β-glucan. β-Glucan-dependent induction of the expression of HSP70 and mucin proteins and suppression of the expression of pro-inflammatory cytokines, chemokines and CAM were also observed in cultured cells in vitro. The results of the present study suggest that β-glucan protects the gastric mucosa from the formation of irritant-induced lesions by increasing the levels of defensive factors, such as HSP70 and mucin.

Original languageEnglish
Pages (from-to)475-485
Number of pages11
JournalBritish Journal of Nutrition
Volume106
Issue number4
DOIs
Publication statusPublished - 2011 Aug 28
Externally publishedYes

Fingerprint

Glucans
Irritants
Stomach
Mucins
Cell Adhesion Molecules
Gastric Mucosa
Chemokines
Cytokines
HSP70 Heat-Shock Proteins
Neutrophil Infiltration
Dinoprostone
Oral Administration
Cultured Cells
Ethanol
Pharmacology
Infection
Neoplasms

Keywords

  • β-(1,3→1,6)-d-Glucan
  • Ethanol
  • Gastric lesions
  • Heat shock protein 70
  • Mucin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Protective effect of β-(1,3→1,6)-d-glucan against irritant-induced gastric lesions. / Tanaka, Ken Ichiro; Tanaka, Yuta; Suzuki, Toshio; Mizushima, Tohru.

In: British Journal of Nutrition, Vol. 106, No. 4, 28.08.2011, p. 475-485.

Research output: Contribution to journalArticle

Tanaka, Ken Ichiro ; Tanaka, Yuta ; Suzuki, Toshio ; Mizushima, Tohru. / Protective effect of β-(1,3→1,6)-d-glucan against irritant-induced gastric lesions. In: British Journal of Nutrition. 2011 ; Vol. 106, No. 4. pp. 475-485.
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