Abstract
β-(1,3)-d-Glucan with β-(1,6) branches has been reported to have various pharmacological activities, such as anti-tumour and anti-infection activities, which result from its immunomodulating effects. Gastric lesions result from an imbalance between aggressive and defensive factors. In the present study, we examined the effect of β-(1,3)-d-glucan with β-(1,6) branches isolated from Aureobasidium pullulans on the gastric ulcerogenic response in mice. Oral administration of β-glucan ameliorated gastric lesions induced by ethanol (EtOH) or HCl. This administration of β-glucan also suppressed EtOH-induced inflammatory responses, such as infiltration of neutrophils and expression of pro-inflammatory cytokines, chemokines and cell adhesion molecules (CAM) at the gastric mucosa. Of the various defensive factors, the levels of heat shock protein (HSP) 70 and mucin but not PGE2 were increased by the administration of β-glucan. β-Glucan-dependent induction of the expression of HSP70 and mucin proteins and suppression of the expression of pro-inflammatory cytokines, chemokines and CAM were also observed in cultured cells in vitro. The results of the present study suggest that β-glucan protects the gastric mucosa from the formation of irritant-induced lesions by increasing the levels of defensive factors, such as HSP70 and mucin.
| Original language | English |
|---|---|
| Pages (from-to) | 475-485 |
| Number of pages | 11 |
| Journal | British Journal of Nutrition |
| Volume | 106 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Aug 28 |
| Externally published | Yes |
Fingerprint
Keywords
- β-(1,3→1,6)-d-Glucan
- Ethanol
- Gastric lesions
- Heat shock protein 70
- Mucin
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Protective effect of β-(1,3→1,6)-d-glucan against irritant-induced gastric lesions. / Tanaka, Ken Ichiro; Tanaka, Yuta; Suzuki, Toshio; Mizushima, Tohru.
In: British Journal of Nutrition, Vol. 106, No. 4, 28.08.2011, p. 475-485.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective effect of β-(1,3→1,6)-d-glucan against irritant-induced gastric lesions
AU - Tanaka, Ken Ichiro
AU - Tanaka, Yuta
AU - Suzuki, Toshio
AU - Mizushima, Tohru
PY - 2011/8/28
Y1 - 2011/8/28
N2 - β-(1,3)-d-Glucan with β-(1,6) branches has been reported to have various pharmacological activities, such as anti-tumour and anti-infection activities, which result from its immunomodulating effects. Gastric lesions result from an imbalance between aggressive and defensive factors. In the present study, we examined the effect of β-(1,3)-d-glucan with β-(1,6) branches isolated from Aureobasidium pullulans on the gastric ulcerogenic response in mice. Oral administration of β-glucan ameliorated gastric lesions induced by ethanol (EtOH) or HCl. This administration of β-glucan also suppressed EtOH-induced inflammatory responses, such as infiltration of neutrophils and expression of pro-inflammatory cytokines, chemokines and cell adhesion molecules (CAM) at the gastric mucosa. Of the various defensive factors, the levels of heat shock protein (HSP) 70 and mucin but not PGE2 were increased by the administration of β-glucan. β-Glucan-dependent induction of the expression of HSP70 and mucin proteins and suppression of the expression of pro-inflammatory cytokines, chemokines and CAM were also observed in cultured cells in vitro. The results of the present study suggest that β-glucan protects the gastric mucosa from the formation of irritant-induced lesions by increasing the levels of defensive factors, such as HSP70 and mucin.
AB - β-(1,3)-d-Glucan with β-(1,6) branches has been reported to have various pharmacological activities, such as anti-tumour and anti-infection activities, which result from its immunomodulating effects. Gastric lesions result from an imbalance between aggressive and defensive factors. In the present study, we examined the effect of β-(1,3)-d-glucan with β-(1,6) branches isolated from Aureobasidium pullulans on the gastric ulcerogenic response in mice. Oral administration of β-glucan ameliorated gastric lesions induced by ethanol (EtOH) or HCl. This administration of β-glucan also suppressed EtOH-induced inflammatory responses, such as infiltration of neutrophils and expression of pro-inflammatory cytokines, chemokines and cell adhesion molecules (CAM) at the gastric mucosa. Of the various defensive factors, the levels of heat shock protein (HSP) 70 and mucin but not PGE2 were increased by the administration of β-glucan. β-Glucan-dependent induction of the expression of HSP70 and mucin proteins and suppression of the expression of pro-inflammatory cytokines, chemokines and CAM were also observed in cultured cells in vitro. The results of the present study suggest that β-glucan protects the gastric mucosa from the formation of irritant-induced lesions by increasing the levels of defensive factors, such as HSP70 and mucin.
KW - β-(1,3→1,6)-d-Glucan
KW - Ethanol
KW - Gastric lesions
KW - Heat shock protein 70
KW - Mucin
UR - http://www.scopus.com/inward/record.url?scp=80052962695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052962695&partnerID=8YFLogxK
U2 - 10.1017/S0007114511000365
DO - 10.1017/S0007114511000365
M3 - Article
C2 - 21443814
AN - SCOPUS:80052962695
VL - 106
SP - 475
EP - 485
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 4
ER -