Proteinuria is a prognostic marker for cardiovascular mortality

NIPPON DATA 80, 1980-1999

Shinichi Tanihara, Takehito Hayakawa, Izumi Oki, Yosikazu Nakamura, Kiyomi Sakata, Akira Okayama, Yasuyuki Fujita, Hirotsugu Ueshima, Osamu Iimura, Teruo Omae, Kazuo Ueda, Hiroshi Yanagawa, Kazunori Kodama, Fumiyoshi Kasagi, Tomonori Okamura, Yoshikuni Kita, Shigeyuki Saito, Kiyomi Sakata, Shinichi Tanihara, Hiroshi Horibe & 12 others Masumi Minowa, Toshihiro Takeuchi, Mitsuru Hasebe, Fumitsugu Kusano, Katsuhiko Kawaminami, Sohel R. Choudhury, Yutaka Kiyohara, Minoru Iida, Tsutomu Hashimoto, Atsushi Terao, Koryo Sawai, Shigeo Shibata

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalJournal of Epidemiology
Volume15
Issue number4
DOIs
Publication statusPublished - 2005
Externally publishedYes

Fingerprint

Proteinuria
Mortality
Diabetes Mellitus
Cardiovascular Diseases
Stroke
Population
Heart Diseases
Creatinine
Japan
Hypertension
Kidney
Serum
Proteins

Keywords

  • Cardiovascular diseases
  • Cohort studies
  • Japan
  • Mortality
  • Proteinuria

ASJC Scopus subject areas

  • Epidemiology

Cite this

Tanihara, S., Hayakawa, T., Oki, I., Nakamura, Y., Sakata, K., Okayama, A., ... Shibata, S. (2005). Proteinuria is a prognostic marker for cardiovascular mortality: NIPPON DATA 80, 1980-1999. Journal of Epidemiology, 15(4), 146-153. https://doi.org/10.2188/jea.15.146

Proteinuria is a prognostic marker for cardiovascular mortality : NIPPON DATA 80, 1980-1999. / Tanihara, Shinichi; Hayakawa, Takehito; Oki, Izumi; Nakamura, Yosikazu; Sakata, Kiyomi; Okayama, Akira; Fujita, Yasuyuki; Ueshima, Hirotsugu; Iimura, Osamu; Omae, Teruo; Ueda, Kazuo; Yanagawa, Hiroshi; Kodama, Kazunori; Kasagi, Fumiyoshi; Okamura, Tomonori; Kita, Yoshikuni; Saito, Shigeyuki; Sakata, Kiyomi; Tanihara, Shinichi; Horibe, Hiroshi; Minowa, Masumi; Takeuchi, Toshihiro; Hasebe, Mitsuru; Kusano, Fumitsugu; Kawaminami, Katsuhiko; Choudhury, Sohel R.; Kiyohara, Yutaka; Iida, Minoru; Hashimoto, Tsutomu; Terao, Atsushi; Sawai, Koryo; Shibata, Shigeo.

In: Journal of Epidemiology, Vol. 15, No. 4, 2005, p. 146-153.

Research output: Contribution to journalArticle

Tanihara, S, Hayakawa, T, Oki, I, Nakamura, Y, Sakata, K, Okayama, A, Fujita, Y, Ueshima, H, Iimura, O, Omae, T, Ueda, K, Yanagawa, H, Kodama, K, Kasagi, F, Okamura, T, Kita, Y, Saito, S, Sakata, K, Tanihara, S, Horibe, H, Minowa, M, Takeuchi, T, Hasebe, M, Kusano, F, Kawaminami, K, Choudhury, SR, Kiyohara, Y, Iida, M, Hashimoto, T, Terao, A, Sawai, K & Shibata, S 2005, 'Proteinuria is a prognostic marker for cardiovascular mortality: NIPPON DATA 80, 1980-1999', Journal of Epidemiology, vol. 15, no. 4, pp. 146-153. https://doi.org/10.2188/jea.15.146
Tanihara, Shinichi ; Hayakawa, Takehito ; Oki, Izumi ; Nakamura, Yosikazu ; Sakata, Kiyomi ; Okayama, Akira ; Fujita, Yasuyuki ; Ueshima, Hirotsugu ; Iimura, Osamu ; Omae, Teruo ; Ueda, Kazuo ; Yanagawa, Hiroshi ; Kodama, Kazunori ; Kasagi, Fumiyoshi ; Okamura, Tomonori ; Kita, Yoshikuni ; Saito, Shigeyuki ; Sakata, Kiyomi ; Tanihara, Shinichi ; Horibe, Hiroshi ; Minowa, Masumi ; Takeuchi, Toshihiro ; Hasebe, Mitsuru ; Kusano, Fumitsugu ; Kawaminami, Katsuhiko ; Choudhury, Sohel R. ; Kiyohara, Yutaka ; Iida, Minoru ; Hashimoto, Tsutomu ; Terao, Atsushi ; Sawai, Koryo ; Shibata, Shigeo. / Proteinuria is a prognostic marker for cardiovascular mortality : NIPPON DATA 80, 1980-1999. In: Journal of Epidemiology. 2005 ; Vol. 15, No. 4. pp. 146-153.
@article{13a5c8054a544191bcb10fa7c562c828,
title = "Proteinuria is a prognostic marker for cardiovascular mortality: NIPPON DATA 80, 1980-1999",
abstract = "Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.",
keywords = "Cardiovascular diseases, Cohort studies, Japan, Mortality, Proteinuria",
author = "Shinichi Tanihara and Takehito Hayakawa and Izumi Oki and Yosikazu Nakamura and Kiyomi Sakata and Akira Okayama and Yasuyuki Fujita and Hirotsugu Ueshima and Osamu Iimura and Teruo Omae and Kazuo Ueda and Hiroshi Yanagawa and Kazunori Kodama and Fumiyoshi Kasagi and Tomonori Okamura and Yoshikuni Kita and Shigeyuki Saito and Kiyomi Sakata and Shinichi Tanihara and Hiroshi Horibe and Masumi Minowa and Toshihiro Takeuchi and Mitsuru Hasebe and Fumitsugu Kusano and Katsuhiko Kawaminami and Choudhury, {Sohel R.} and Yutaka Kiyohara and Minoru Iida and Tsutomu Hashimoto and Atsushi Terao and Koryo Sawai and Shigeo Shibata",
year = "2005",
doi = "10.2188/jea.15.146",
language = "English",
volume = "15",
pages = "146--153",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "4",

}

TY - JOUR

T1 - Proteinuria is a prognostic marker for cardiovascular mortality

T2 - NIPPON DATA 80, 1980-1999

AU - Tanihara, Shinichi

AU - Hayakawa, Takehito

AU - Oki, Izumi

AU - Nakamura, Yosikazu

AU - Sakata, Kiyomi

AU - Okayama, Akira

AU - Fujita, Yasuyuki

AU - Ueshima, Hirotsugu

AU - Iimura, Osamu

AU - Omae, Teruo

AU - Ueda, Kazuo

AU - Yanagawa, Hiroshi

AU - Kodama, Kazunori

AU - Kasagi, Fumiyoshi

AU - Okamura, Tomonori

AU - Kita, Yoshikuni

AU - Saito, Shigeyuki

AU - Sakata, Kiyomi

AU - Tanihara, Shinichi

AU - Horibe, Hiroshi

AU - Minowa, Masumi

AU - Takeuchi, Toshihiro

AU - Hasebe, Mitsuru

AU - Kusano, Fumitsugu

AU - Kawaminami, Katsuhiko

AU - Choudhury, Sohel R.

AU - Kiyohara, Yutaka

AU - Iida, Minoru

AU - Hashimoto, Tsutomu

AU - Terao, Atsushi

AU - Sawai, Koryo

AU - Shibata, Shigeo

PY - 2005

Y1 - 2005

N2 - Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.

AB - Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.

KW - Cardiovascular diseases

KW - Cohort studies

KW - Japan

KW - Mortality

KW - Proteinuria

UR - http://www.scopus.com/inward/record.url?scp=25444457293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444457293&partnerID=8YFLogxK

U2 - 10.2188/jea.15.146

DO - 10.2188/jea.15.146

M3 - Article

VL - 15

SP - 146

EP - 153

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 4

ER -