Proteolipid protein 2 is associated with melanoma metastasis

Yoshiko Sonoda, Masako Warita, Takaharu Suzuki, Hiroki Ozawa, Yusuke Fukuda, Megumi Funakoshi-Tago, Tadashi Kasahara

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14 Citations (Scopus)

Abstract

The metastasis of malignant tumor cells from the primary tumor to distant sites in the body is a complex process. To identify genes that may be essential for metastasis, we established poorly metastatic mouse melanoma cells, namely Y925F-mutated FAK-transfected cells (Y925F cells), from the highly metastatic mouse melanoma cell line B16F10, and performed expression analyses. The expression of phospholipid protein 2 (PLP2) was markedly down-regulated in the Y925F cells. To elucidate the function of PLP2, we established melanoma cells overexpressing PLP2. We found that PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo. These results suggest that PLP2 aids metastasis. Furthermore, we showed that PLP2 binds specifically to PI3K, thus activating Akt.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalOncology reports
Volume23
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

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Keywords

  • Akt
  • FAK
  • Melanoma
  • Metastasis
  • PI3K
  • PLP2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sonoda, Y., Warita, M., Suzuki, T., Ozawa, H., Fukuda, Y., Funakoshi-Tago, M., & Kasahara, T. (2010). Proteolipid protein 2 is associated with melanoma metastasis. Oncology reports, 23(2), 371-376. https://doi.org/10.3892/or-00000645