Proteomic analysis of plasma proteins in Japanese semisuper centenarians

Yuri Miura, Yuji Sato, Yasumichi Arai, Yukiko Abe, Michiyo Takayama, Tosifusa Toda, Nobuyoshi Hirose, Tamao Endo

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21 Citations (Scopus)

Abstract

We performed proteomic analysis of plasma proteins in Japanese semisuper centenarians (SSCs) (>105years) and young controls (20-39years), and found that 18 protein spots were altered in the plasma of SSCs. From peptide mass fingerprinting following in-gel digestion, it was demonstrated that paraoxonase/arylesterase 1 (PON 1) and apolipoprotein E were decreased, while haptoglobin β-chain, α1-microglobulin, and clusterin precursor were increased in SSCs. Interestingly, proteins related to oxidative stress, PON1, haptoglobin, α1-microglobulin, and clusterin, were altered in SSCs. These results suggest that systemic redox regulation is important for the longevity of SSCs. Overall, proteomics analysis is a powerful technique to search for useful biomarkers for future studies in gerontology and to characterize the individual proteins associated with successful aging of SSCs.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalExperimental Gerontology
Volume46
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Keywords

  • Aging
  • Oxidative stress
  • Plasma proteins
  • Proteomics
  • Semisuper centenarian

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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