Abstract
Psoriatic arthritis (PsA) is considered as one of the seronegative spondylarthropathies. Like rheumatoid arthritis (RA), the increased production of interleukin (IL)-6 suggests a pathogenic role of IL-6 in PsA. However, whether humanized anti-IL-6 receptor antibody such as tocilizumab (TCZ) might be effective for PsA as well as RA has yet to be determined. We report herein two cases of PsA treated using TCZ. Although, TCZ treatment resulted in disappearance of serum CRP in both patients, arthritis and skin lesions were not improved despite 6-month administration of TCZ. In contrast, tumor necrosis factor (TNF) inhibitor proved effective against arthritis and skin lesions in these patients. Collectively, these findings not only indicate that IL-6 has distinct pathological roles in RA and PsA, but also suggest that TNF inhibitor therapy (but not TCZ) is effective for arthritis and skin lesions of PsA.
| Original language | English |
|---|---|
| Pages (from-to) | 85-87 |
| Number of pages | 3 |
| Journal | Joint Bone Spine |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 Jan |
| Externally published | Yes |
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Keywords
- Psoriatic Arthritis
- Tocilizumab
ASJC Scopus subject areas
- Rheumatology
Cite this
Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab. / Ogata, Atsushi; Umegaki, Noriko; Katayama, Ichiro; Kumanogoh, Atsushi; Tanaka, Toshio.
In: Joint Bone Spine, Vol. 79, No. 1, 01.2012, p. 85-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab
AU - Ogata, Atsushi
AU - Umegaki, Noriko
AU - Katayama, Ichiro
AU - Kumanogoh, Atsushi
AU - Tanaka, Toshio
PY - 2012/1
Y1 - 2012/1
N2 - Psoriatic arthritis (PsA) is considered as one of the seronegative spondylarthropathies. Like rheumatoid arthritis (RA), the increased production of interleukin (IL)-6 suggests a pathogenic role of IL-6 in PsA. However, whether humanized anti-IL-6 receptor antibody such as tocilizumab (TCZ) might be effective for PsA as well as RA has yet to be determined. We report herein two cases of PsA treated using TCZ. Although, TCZ treatment resulted in disappearance of serum CRP in both patients, arthritis and skin lesions were not improved despite 6-month administration of TCZ. In contrast, tumor necrosis factor (TNF) inhibitor proved effective against arthritis and skin lesions in these patients. Collectively, these findings not only indicate that IL-6 has distinct pathological roles in RA and PsA, but also suggest that TNF inhibitor therapy (but not TCZ) is effective for arthritis and skin lesions of PsA.
AB - Psoriatic arthritis (PsA) is considered as one of the seronegative spondylarthropathies. Like rheumatoid arthritis (RA), the increased production of interleukin (IL)-6 suggests a pathogenic role of IL-6 in PsA. However, whether humanized anti-IL-6 receptor antibody such as tocilizumab (TCZ) might be effective for PsA as well as RA has yet to be determined. We report herein two cases of PsA treated using TCZ. Although, TCZ treatment resulted in disappearance of serum CRP in both patients, arthritis and skin lesions were not improved despite 6-month administration of TCZ. In contrast, tumor necrosis factor (TNF) inhibitor proved effective against arthritis and skin lesions in these patients. Collectively, these findings not only indicate that IL-6 has distinct pathological roles in RA and PsA, but also suggest that TNF inhibitor therapy (but not TCZ) is effective for arthritis and skin lesions of PsA.
KW - Psoriatic Arthritis
KW - Tocilizumab
UR - http://www.scopus.com/inward/record.url?scp=84855716888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855716888&partnerID=8YFLogxK
U2 - 10.1016/j.jbspin.2011.06.011
DO - 10.1016/j.jbspin.2011.06.011
M3 - Article
C2 - 21962389
AN - SCOPUS:84855716888
VL - 79
SP - 85
EP - 87
JO - Revue du Rhumatisme (English Edition)
JF - Revue du Rhumatisme (English Edition)
SN - 1169-8446
IS - 1
ER -