Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

Gulzar Hussain Shah, Kazuhiro Kataoka, Akiko Ueno, Yoshihisa Ohtsuka, Tohru Mizushima, Kazuhisa Sekimizu

Research output: Contribution to journalArticle

Abstract

The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

Original languageEnglish
Pages (from-to)1233-1234
Number of pages2
JournalBiological and Pharmaceutical Bulletin
Volume20
Issue number12
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Type I DNA Topoisomerase
Cardiolipins
Psychotropic Drugs
Local Anesthetics
Phospholipids
Promethazine
Imipramine
Chlorpromazine
DNA
Pharmaceutical Preparations
calf thymus DNA

Keywords

  • Acidic phospholipid
  • Cardiolipin
  • Chlorpromazine
  • Cytotoxicity
  • DNA topoisomerase 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Shah, G. H., Kataoka, K., Ueno, A., Ohtsuka, Y., Mizushima, T., & Sekimizu, K. (1997). Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity. Biological and Pharmaceutical Bulletin, 20(12), 1233-1234.

Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity. / Shah, Gulzar Hussain; Kataoka, Kazuhiro; Ueno, Akiko; Ohtsuka, Yoshihisa; Mizushima, Tohru; Sekimizu, Kazuhisa.

In: Biological and Pharmaceutical Bulletin, Vol. 20, No. 12, 1997, p. 1233-1234.

Research output: Contribution to journalArticle

Shah, GH, Kataoka, K, Ueno, A, Ohtsuka, Y, Mizushima, T & Sekimizu, K 1997, 'Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity', Biological and Pharmaceutical Bulletin, vol. 20, no. 12, pp. 1233-1234.
Shah, Gulzar Hussain ; Kataoka, Kazuhiro ; Ueno, Akiko ; Ohtsuka, Yoshihisa ; Mizushima, Tohru ; Sekimizu, Kazuhisa. / Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity. In: Biological and Pharmaceutical Bulletin. 1997 ; Vol. 20, No. 12. pp. 1233-1234.
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