The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.
|Number of pages||2|
|Journal||Biological and Pharmaceutical Bulletin|
|Publication status||Published - 1997 Jan 1|
- Acidic phospholipid
- DNA topoisomerase 1
ASJC Scopus subject areas
- Pharmaceutical Science