Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

Gulzar Hussain Shah; Kazuhiro Kataoka; Akiko Ueno; Yoshihisa Ohtsuka; Tohru Mizushima; Kazuhisa Sekimizu

doi:10.1248/bpb.20.1233

Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

Gulzar Hussain Shah, Kazuhiro Kataoka, Akiko Ueno, Yoshihisa Ohtsuka, Tohru Mizushima, Kazuhisa Sekimizu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

Original language	English
Pages (from-to)	1233-1234
Number of pages	2
Journal	Biological and Pharmaceutical Bulletin
Volume	20
Issue number	12
DOIs	https://doi.org/10.1248/bpb.20.1233
Publication status	Published - 1997 Jan 1

Keywords

Acidic phospholipid
Cardiolipin
Chlorpromazine
Cytotoxicity
DNA topoisomerase 1

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.20.1233

Cite this

@article{f39bfc9013394fc3a16ac2a4a980048a,

title = "Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity",

abstract = "The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.",

keywords = "Acidic phospholipid, Cardiolipin, Chlorpromazine, Cytotoxicity, DNA topoisomerase 1",

author = "Shah, {Gulzar Hussain} and Kazuhiro Kataoka and Akiko Ueno and Yoshihisa Ohtsuka and Tohru Mizushima and Kazuhisa Sekimizu",

year = "1997",

month = jan,

day = "1",

doi = "10.1248/bpb.20.1233",

language = "English",

volume = "20",

pages = "1233--1234",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "12",

}

TY - JOUR

T1 - Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

AU - Shah, Gulzar Hussain

AU - Kataoka, Kazuhiro

AU - Ueno, Akiko

AU - Ohtsuka, Yoshihisa

AU - Mizushima, Tohru

AU - Sekimizu, Kazuhisa

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

AB - The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

KW - Acidic phospholipid

KW - Cardiolipin

KW - Chlorpromazine

KW - Cytotoxicity

KW - DNA topoisomerase 1

UR - http://www.scopus.com/inward/record.url?scp=0031455236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031455236&partnerID=8YFLogxK

U2 - 10.1248/bpb.20.1233

DO - 10.1248/bpb.20.1233

M3 - Article

C2 - 9448094

AN - SCOPUS:0031455236

SN - 0918-6158

VL - 20

SP - 1233

EP - 1234

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 12

ER -

Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this