Pulmonary adenocarcinoma associated with SAPHO syndrome difficult to differentiate from multiple bone metastasis

Reishi Shibakuki, Takashi Seto, Kazutsugu Uematsu, Kenji Shimizu, Nobuhiko Seki, Makiko Nakano, Hiroshi Ishii, Mayuko Ohta, Kenji Eguchi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The patient was a 57-year-old man with a chief complaint of anterior chest pain who was diagnosed with clinical stage IV (c-T2N2M1) non-small-cell lung cancer (adenocarcinoma). Tenderness in the sternoclavicular joint, acne, periodontitis, and palmoplantar pustulosis were evident, and SAPHO syndrome was diagnosed. SAPHO syndrome is a rare disorder that results in synovitis, acne, pustulosis, hyperostosis, and osteomyelitis. Bone scintigraphy showed tracer accumulation in the costal cartilage, sternoclavicular joint, and cervical vertebrae 6-7. Although the bone lesions of SAPHO syndrome were difficult to differentiate from bone metastasis of pulmonary adenocarcinoma, metastatic bone tumors were ruled out by magnetic resonance imaging, computed tomography, and fluorodeoxyglucose positron emission tomography. There have been no previously reported cases of lung cancer with comorbid SAPHO syndrome. We report such a case and discuss the relevant literature, particularly that concerned with the evaluation of bone lesions.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalInternal Medicine
Volume45
Issue number8
DOIs
Publication statusPublished - 2006 May 15
Externally publishedYes

Keywords

  • Non-small-cell lung cancer
  • SAPHO syndrome Metastatic bone tumor

ASJC Scopus subject areas

  • Internal Medicine

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