Abstract
A 57-year-old man with myelodysplastic syndrome developed dyspnea on exertion in September 1993. Chest X-ray film showed diffuse infiltrative shadows in the middle and lower lung fields on both sides. The infiltrates were prominent in the perihilar regions but less so in the periphery, consistent with a 'bat wing pattern.' Milky fluid was obtained by bronchoalveolar lavage. The specimens obtained from transbrochial lung biopsy were compatible with the pathological findings of pulmonary alveolar proteinosis with amorphous periodic acid-Sciff-positive materials in the alveolar spaces. Impaired function of alveolar macrophages was demonstrated from their abnormally low phagocytosis of FITC-labeled latex beads. Whole lung lavage under general anesthesia was done twice, but the patient died because of progression of respiratory failure.
| Original language | English |
|---|---|
| Pages (from-to) | 645-651 |
| Number of pages | 7 |
| Journal | Japanese Journal of Thoracic Diseases |
| Volume | 33 |
| Issue number | 6 |
| Publication status | Published - 1995 |
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Keywords
- Alveolar macrophage
- Myelodysplastic syndrome
- Phagocytic activity
- Pulmonary proteinosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Pulmonary alveolar proteinosis associated with myelodysplastic syndrome. / Terashima, T.; Nakamura, H.; Meguro, Shu; Fujimori, H.; Mori, Masaaki; Yamaguchi, K.; Kanazawa, M.; Kato, R.; Kobayashi, K.
In: Japanese Journal of Thoracic Diseases, Vol. 33, No. 6, 1995, p. 645-651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary alveolar proteinosis associated with myelodysplastic syndrome
AU - Terashima, T.
AU - Nakamura, H.
AU - Meguro, Shu
AU - Fujimori, H.
AU - Mori, Masaaki
AU - Yamaguchi, K.
AU - Kanazawa, M.
AU - Kato, R.
AU - Kobayashi, K.
PY - 1995
Y1 - 1995
N2 - A 57-year-old man with myelodysplastic syndrome developed dyspnea on exertion in September 1993. Chest X-ray film showed diffuse infiltrative shadows in the middle and lower lung fields on both sides. The infiltrates were prominent in the perihilar regions but less so in the periphery, consistent with a 'bat wing pattern.' Milky fluid was obtained by bronchoalveolar lavage. The specimens obtained from transbrochial lung biopsy were compatible with the pathological findings of pulmonary alveolar proteinosis with amorphous periodic acid-Sciff-positive materials in the alveolar spaces. Impaired function of alveolar macrophages was demonstrated from their abnormally low phagocytosis of FITC-labeled latex beads. Whole lung lavage under general anesthesia was done twice, but the patient died because of progression of respiratory failure.
AB - A 57-year-old man with myelodysplastic syndrome developed dyspnea on exertion in September 1993. Chest X-ray film showed diffuse infiltrative shadows in the middle and lower lung fields on both sides. The infiltrates were prominent in the perihilar regions but less so in the periphery, consistent with a 'bat wing pattern.' Milky fluid was obtained by bronchoalveolar lavage. The specimens obtained from transbrochial lung biopsy were compatible with the pathological findings of pulmonary alveolar proteinosis with amorphous periodic acid-Sciff-positive materials in the alveolar spaces. Impaired function of alveolar macrophages was demonstrated from their abnormally low phagocytosis of FITC-labeled latex beads. Whole lung lavage under general anesthesia was done twice, but the patient died because of progression of respiratory failure.
KW - Alveolar macrophage
KW - Myelodysplastic syndrome
KW - Phagocytic activity
KW - Pulmonary proteinosis
UR - http://www.scopus.com/inward/record.url?scp=0029049947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029049947&partnerID=8YFLogxK
M3 - Article
C2 - 7666621
AN - SCOPUS:0029049947
VL - 33
SP - 645
EP - 651
JO - Respiratory Investigation
JF - Respiratory Investigation
SN - 2212-5345
IS - 6
ER -