Pulmonary effects in workers exposed to indium metal: A cross-sectional study

Makiko Nakano, Akiyo Tanaka, Miyuki Hirata, Satoko Iwasawa, Kazuyuki Omae

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: Indium was added to the list of substances regulated by the Ordinance on Prevention of Hazards due to Specified Chemical Substances (OPHSCS) in 2013. Indium metal (IM), however, is not regulated by the OPHSCS due to insufficient information on pulmonary effects following exposure. Methods: From 2011 to 2013, a cross-sectional study was conducted on 141 IM-exposed workers at 11 factories. Subjective symptoms were assessed, including levels of serum biomarkers, spirometry readings and total and diffuse lung capacity. Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) were selected as biomarkers of interstitial pneumonia. Indium serum concentration (In-S) and personal air sampling data were used to estimate exposure. Subjects were categorized into 5 groups based on occupation and type of exposure: smelting, soldering, dental technician, bonding and other. Results: The highest level of In-S was 25.4 μg/l, and the mean In-S level was significantly higher in the smelting group than in other groups. In the smelting group, the prevalence of increased In-S levels was 9.1%, while that of abnormal KL-6 was 15.2%. A significant dose-effect relationship was observed between the In-S and KL-6 levels. No marked differences were observed between any of the groups in SP-D values, pulmonary symptoms, or pulmonary function test results. A total of 31% of the subjects worked in an environment with IM levels exceeding 0.3 μg/m<sup>3</sup>, which requires a protective mask to be worn. Conclusions: For workers exposed to IM, work environments should be monitored, appropriate protective masks should be worn, and medical monitoring should be conducted according to the OPHSCS.

Original languageEnglish
Pages (from-to)346-352
Number of pages7
JournalJournal of Occupational Health
Volume57
Issue number4
Publication statusPublished - 2015

Fingerprint

Indium
Cross-Sectional Studies
Metals
Lung
Smelting
Serum
Pulmonary Surfactant-Associated Protein D
Hazards
Biomarkers
Masks
Dental Bonding
Dental Technicians
Total Lung Capacity
Patient monitoring
Spirometry
Respiratory Function Tests
Interstitial Lung Diseases
Soldering
Occupations
Industrial plants

Keywords

  • Cross-sectional study
  • Indium concentration
  • Indium metal
  • Interstitial pneumonia
  • Krebs von den Lungen-6 (KL-6)
  • Surfactant protein D (SP-D)

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Nakano, M., Tanaka, A., Hirata, M., Iwasawa, S., & Omae, K. (2015). Pulmonary effects in workers exposed to indium metal: A cross-sectional study. Journal of Occupational Health, 57(4), 346-352.

Pulmonary effects in workers exposed to indium metal : A cross-sectional study. / Nakano, Makiko; Tanaka, Akiyo; Hirata, Miyuki; Iwasawa, Satoko; Omae, Kazuyuki.

In: Journal of Occupational Health, Vol. 57, No. 4, 2015, p. 346-352.

Research output: Contribution to journalArticle

Nakano, M, Tanaka, A, Hirata, M, Iwasawa, S & Omae, K 2015, 'Pulmonary effects in workers exposed to indium metal: A cross-sectional study', Journal of Occupational Health, vol. 57, no. 4, pp. 346-352.
Nakano, Makiko ; Tanaka, Akiyo ; Hirata, Miyuki ; Iwasawa, Satoko ; Omae, Kazuyuki. / Pulmonary effects in workers exposed to indium metal : A cross-sectional study. In: Journal of Occupational Health. 2015 ; Vol. 57, No. 4. pp. 346-352.
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abstract = "Objectives: Indium was added to the list of substances regulated by the Ordinance on Prevention of Hazards due to Specified Chemical Substances (OPHSCS) in 2013. Indium metal (IM), however, is not regulated by the OPHSCS due to insufficient information on pulmonary effects following exposure. Methods: From 2011 to 2013, a cross-sectional study was conducted on 141 IM-exposed workers at 11 factories. Subjective symptoms were assessed, including levels of serum biomarkers, spirometry readings and total and diffuse lung capacity. Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) were selected as biomarkers of interstitial pneumonia. Indium serum concentration (In-S) and personal air sampling data were used to estimate exposure. Subjects were categorized into 5 groups based on occupation and type of exposure: smelting, soldering, dental technician, bonding and other. Results: The highest level of In-S was 25.4 μg/l, and the mean In-S level was significantly higher in the smelting group than in other groups. In the smelting group, the prevalence of increased In-S levels was 9.1{\%}, while that of abnormal KL-6 was 15.2{\%}. A significant dose-effect relationship was observed between the In-S and KL-6 levels. No marked differences were observed between any of the groups in SP-D values, pulmonary symptoms, or pulmonary function test results. A total of 31{\%} of the subjects worked in an environment with IM levels exceeding 0.3 μg/m3, which requires a protective mask to be worn. Conclusions: For workers exposed to IM, work environments should be monitored, appropriate protective masks should be worn, and medical monitoring should be conducted according to the OPHSCS.",
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AB - Objectives: Indium was added to the list of substances regulated by the Ordinance on Prevention of Hazards due to Specified Chemical Substances (OPHSCS) in 2013. Indium metal (IM), however, is not regulated by the OPHSCS due to insufficient information on pulmonary effects following exposure. Methods: From 2011 to 2013, a cross-sectional study was conducted on 141 IM-exposed workers at 11 factories. Subjective symptoms were assessed, including levels of serum biomarkers, spirometry readings and total and diffuse lung capacity. Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) were selected as biomarkers of interstitial pneumonia. Indium serum concentration (In-S) and personal air sampling data were used to estimate exposure. Subjects were categorized into 5 groups based on occupation and type of exposure: smelting, soldering, dental technician, bonding and other. Results: The highest level of In-S was 25.4 μg/l, and the mean In-S level was significantly higher in the smelting group than in other groups. In the smelting group, the prevalence of increased In-S levels was 9.1%, while that of abnormal KL-6 was 15.2%. A significant dose-effect relationship was observed between the In-S and KL-6 levels. No marked differences were observed between any of the groups in SP-D values, pulmonary symptoms, or pulmonary function test results. A total of 31% of the subjects worked in an environment with IM levels exceeding 0.3 μg/m3, which requires a protective mask to be worn. Conclusions: For workers exposed to IM, work environments should be monitored, appropriate protective masks should be worn, and medical monitoring should be conducted according to the OPHSCS.

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