Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis

Kazuhiro Mori, Kazushige Ikeda, Shinya Hayashida, Keisuke Tokieda, Hitoshi Ishimoto, Yoshihiro Fujii, Ryuji Fukuzawa, Yoshihiro Kitano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Purpose: Cellular differentiation of pulmonary hyperplasia has not been reported in human cases. The authors studied surfactant protein expression and ultrastructure of pulmonary epithelial cells in fetal hyperplastic lungs associated with congenital tracheal agenesis. Methods: The maturation of pulmonary epithelial cells was assessed by immunohistochemical examination for surfactant proteins (SP-A, mature SP-B, proSP-B, proSP-C, and SP-D) and transmission electron microscopy. As controls normal lung portions of 8 fetuses born at 21 weeks gestation were used. Results: Mature SP-B and SP-D was detected in terminal airways in this case, but not in controls. In electron microscopy, lamellar bodies were recognized, and glycogen granules were less abundant in terminal airway cells. Conclusion: The differentiation of pulmonary epithelial cells appeared to be more advanced for the gestational age in pulmonary hyperplasia with congenital tracheal agenesis.

Original languageEnglish
Pages (from-to)1845-1848
Number of pages4
JournalJournal of Pediatric Surgery
Volume36
Issue number12
DOIs
Publication statusPublished - 2001

Fingerprint

Epithelial Cells
Lung
Pulmonary Surfactant-Associated Protein D
Surface-Active Agents
Hyperplasia
Pulmonary Surfactant-Associated Protein A
Tracheal agenesis
Transmission Electron Microscopy
Glycogen
Gestational Age
Electron Microscopy
Fetus
Pregnancy
Proteins

Keywords

  • Electron microscopy
  • Hyperplastic lung
  • Surfactant proteins
  • Tracheal agenesis

ASJC Scopus subject areas

  • Surgery

Cite this

Mori, K., Ikeda, K., Hayashida, S., Tokieda, K., Ishimoto, H., Fujii, Y., ... Kitano, Y. (2001). Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis. Journal of Pediatric Surgery, 36(12), 1845-1848. https://doi.org/10.1053/jpsu.2001.28862

Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis. / Mori, Kazuhiro; Ikeda, Kazushige; Hayashida, Shinya; Tokieda, Keisuke; Ishimoto, Hitoshi; Fujii, Yoshihiro; Fukuzawa, Ryuji; Kitano, Yoshihiro.

In: Journal of Pediatric Surgery, Vol. 36, No. 12, 2001, p. 1845-1848.

Research output: Contribution to journalArticle

Mori, K, Ikeda, K, Hayashida, S, Tokieda, K, Ishimoto, H, Fujii, Y, Fukuzawa, R & Kitano, Y 2001, 'Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis', Journal of Pediatric Surgery, vol. 36, no. 12, pp. 1845-1848. https://doi.org/10.1053/jpsu.2001.28862
Mori, Kazuhiro ; Ikeda, Kazushige ; Hayashida, Shinya ; Tokieda, Keisuke ; Ishimoto, Hitoshi ; Fujii, Yoshihiro ; Fukuzawa, Ryuji ; Kitano, Yoshihiro. / Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis. In: Journal of Pediatric Surgery. 2001 ; Vol. 36, No. 12. pp. 1845-1848.
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AU - Ishimoto, Hitoshi

AU - Fujii, Yoshihiro

AU - Fukuzawa, Ryuji

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AB - Background/Purpose: Cellular differentiation of pulmonary hyperplasia has not been reported in human cases. The authors studied surfactant protein expression and ultrastructure of pulmonary epithelial cells in fetal hyperplastic lungs associated with congenital tracheal agenesis. Methods: The maturation of pulmonary epithelial cells was assessed by immunohistochemical examination for surfactant proteins (SP-A, mature SP-B, proSP-B, proSP-C, and SP-D) and transmission electron microscopy. As controls normal lung portions of 8 fetuses born at 21 weeks gestation were used. Results: Mature SP-B and SP-D was detected in terminal airways in this case, but not in controls. In electron microscopy, lamellar bodies were recognized, and glycogen granules were less abundant in terminal airway cells. Conclusion: The differentiation of pulmonary epithelial cells appeared to be more advanced for the gestational age in pulmonary hyperplasia with congenital tracheal agenesis.

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