Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning

Bao Li Zhu, Kaori Ishida, Li Quan, Dong Ri Li, Mari Taniguchi, Masaki Q Fujita, Hitoshi Maeda, Tsutomu Tsuji

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

To evaluate the immunohistochemical distribution and serum levels of a pulmonary surfactant-associated protein A (SP-A) in fatal drowning with regard to the pulmonary alveolar injury, 53 autopsy cases were investigated. SP-A was membranously or linearly demonstrated in varying intensities on the intra-alveolar interior surface and on the interface of the intra-alveolar effusion. A high score of intra-alveolar aggregates of SP-A was significantly more frequently observed in freshwater than saltwater drowning. The left/right ratios of cardiac blood SP-A level were significantly high both in fresh- and saltwater drowning, showing no relationship to aggregated SP-A scores. Immunohistochemical score and serum level of SP-A were independent of the lung weight or pleural effusion. These observations suggest a partial difference of pulmonary pathophysiology depending on the immersion medium in fatal drowning.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalLegal Medicine
Volume4
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Staphylococcal Protein A
Surface-Active Agents
Immunohistochemistry
Lung
Serum
Fresh Water
Pulmonary Surfactant-Associated Protein A
Lung Injury
Immersion
Pleural Effusion
Autopsy
Weights and Measures

Keywords

  • Drowning
  • Forensic pathophysiology
  • Immunohistochemistry
  • Pulmonary surfactant-associated protein A
  • Serum level

ASJC Scopus subject areas

  • Genetics
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health

Cite this

Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning. / Zhu, Bao Li; Ishida, Kaori; Quan, Li; Li, Dong Ri; Taniguchi, Mari; Fujita, Masaki Q; Maeda, Hitoshi; Tsuji, Tsutomu.

In: Legal Medicine, Vol. 4, No. 1, 2002, p. 1-6.

Research output: Contribution to journalArticle

Zhu, Bao Li ; Ishida, Kaori ; Quan, Li ; Li, Dong Ri ; Taniguchi, Mari ; Fujita, Masaki Q ; Maeda, Hitoshi ; Tsuji, Tsutomu. / Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning. In: Legal Medicine. 2002 ; Vol. 4, No. 1. pp. 1-6.
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