Pulmonary injury by an over-the-counter drug, Nospole G

Yusuke Narita, Katsuhiko Naoki, Naoya Hida, Hiroaki Okamoto

Research output: Contribution to journalArticle

Abstract

A 78-year-old woman was admitted with dyspnea. She had caught a cold and took an over-the-counter drug (Nospole G) for 2 weeks before admission. Chest radiography and CT scanning showed bilateral diffuse and interstitial shadows, and arterial blood gas analysis demonstrated severe hypoxemia. Withdrawal of Nospole and treatment with both corticosteroid and sivelestat sodium resulted in improvement of clinical findings and successful recovery from mechanical ventilation. A drug lymphocyte stimulation test for Nospole G was positive. Based on these findings, we determined that this patient had drug-induced pneumonitis caused by Nospole G. Finally, she died of sepsis caused by multidrug-resistant Staphylococcus aureus (MRSA) infection. In summary, we report here an elderly case of drug-induced pneumonitis successfully weaned from mechanical ventilation by early treatment with corticosteroid and sivelestat sodium, monitored by changes of markers for interstitial pneumonitis (KL-6, SP-A, SP-D).

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume45
Issue number1
Publication statusPublished - 2007 Jan
Externally publishedYes

Fingerprint

Nonprescription Drugs
Lung Injury
Artificial Respiration
Pneumonia
Adrenal Cortex Hormones
Sodium
Pulmonary Surfactant-Associated Protein D
Pharmaceutical Preparations
Blood Gas Analysis
Interstitial Lung Diseases
Lymphocyte Activation
Radiography
Dyspnea
Staphylococcus aureus
Sepsis
Thorax
Therapeutics
Infection
sivelestat

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pulmonary injury by an over-the-counter drug, Nospole G. / Narita, Yusuke; Naoki, Katsuhiko; Hida, Naoya; Okamoto, Hiroaki.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 45, No. 1, 01.2007, p. 13-20.

Research output: Contribution to journalArticle

Narita, Yusuke ; Naoki, Katsuhiko ; Hida, Naoya ; Okamoto, Hiroaki. / Pulmonary injury by an over-the-counter drug, Nospole G. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2007 ; Vol. 45, No. 1. pp. 13-20.
@article{64c1e33eb10d42cd867ff737ca7888d7,
title = "Pulmonary injury by an over-the-counter drug, Nospole G",
abstract = "A 78-year-old woman was admitted with dyspnea. She had caught a cold and took an over-the-counter drug (Nospole G) for 2 weeks before admission. Chest radiography and CT scanning showed bilateral diffuse and interstitial shadows, and arterial blood gas analysis demonstrated severe hypoxemia. Withdrawal of Nospole and treatment with both corticosteroid and sivelestat sodium resulted in improvement of clinical findings and successful recovery from mechanical ventilation. A drug lymphocyte stimulation test for Nospole G was positive. Based on these findings, we determined that this patient had drug-induced pneumonitis caused by Nospole G. Finally, she died of sepsis caused by multidrug-resistant Staphylococcus aureus (MRSA) infection. In summary, we report here an elderly case of drug-induced pneumonitis successfully weaned from mechanical ventilation by early treatment with corticosteroid and sivelestat sodium, monitored by changes of markers for interstitial pneumonitis (KL-6, SP-A, SP-D).",
author = "Yusuke Narita and Katsuhiko Naoki and Naoya Hida and Hiroaki Okamoto",
year = "2007",
month = "1",
language = "English",
volume = "45",
pages = "13--20",
journal = "Respiratory Investigation",
issn = "2212-5345",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Pulmonary injury by an over-the-counter drug, Nospole G

AU - Narita, Yusuke

AU - Naoki, Katsuhiko

AU - Hida, Naoya

AU - Okamoto, Hiroaki

PY - 2007/1

Y1 - 2007/1

N2 - A 78-year-old woman was admitted with dyspnea. She had caught a cold and took an over-the-counter drug (Nospole G) for 2 weeks before admission. Chest radiography and CT scanning showed bilateral diffuse and interstitial shadows, and arterial blood gas analysis demonstrated severe hypoxemia. Withdrawal of Nospole and treatment with both corticosteroid and sivelestat sodium resulted in improvement of clinical findings and successful recovery from mechanical ventilation. A drug lymphocyte stimulation test for Nospole G was positive. Based on these findings, we determined that this patient had drug-induced pneumonitis caused by Nospole G. Finally, she died of sepsis caused by multidrug-resistant Staphylococcus aureus (MRSA) infection. In summary, we report here an elderly case of drug-induced pneumonitis successfully weaned from mechanical ventilation by early treatment with corticosteroid and sivelestat sodium, monitored by changes of markers for interstitial pneumonitis (KL-6, SP-A, SP-D).

AB - A 78-year-old woman was admitted with dyspnea. She had caught a cold and took an over-the-counter drug (Nospole G) for 2 weeks before admission. Chest radiography and CT scanning showed bilateral diffuse and interstitial shadows, and arterial blood gas analysis demonstrated severe hypoxemia. Withdrawal of Nospole and treatment with both corticosteroid and sivelestat sodium resulted in improvement of clinical findings and successful recovery from mechanical ventilation. A drug lymphocyte stimulation test for Nospole G was positive. Based on these findings, we determined that this patient had drug-induced pneumonitis caused by Nospole G. Finally, she died of sepsis caused by multidrug-resistant Staphylococcus aureus (MRSA) infection. In summary, we report here an elderly case of drug-induced pneumonitis successfully weaned from mechanical ventilation by early treatment with corticosteroid and sivelestat sodium, monitored by changes of markers for interstitial pneumonitis (KL-6, SP-A, SP-D).

UR - http://www.scopus.com/inward/record.url?scp=33847693217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847693217&partnerID=8YFLogxK

M3 - Article

C2 - 17313021

AN - SCOPUS:33847693217

VL - 45

SP - 13

EP - 20

JO - Respiratory Investigation

JF - Respiratory Investigation

SN - 2212-5345

IS - 1

ER -