Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists

Application to flow injection for pharmaceutical analysis

Chanpen Karuwan, Thitirat Mantim, Patcharin Chaisuwan, Prapin Wilairat, Kate Grudpan, Piyada Jittangprasert, Yasuaki Einaga, Orawon Chailapakul, Leena Suntornsuk, Oraphan Anurukvorakun, Duangjai Nacapricha

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.

Original languageEnglish
Pages (from-to)1837-1850
Number of pages14
JournalSensors
Volume6
Issue number12
Publication statusPublished - 2006 Dec

Fingerprint

Flow Injection Analysis
antifouling
Diamond
Boron
Fouling
Terbutaline
Drug products
Albuterol
Diamonds
boron
diamonds
Clenbuterol
injection
Diamond films
Pharmaceutical Preparations
Capillary electrophoresis
Capillary Electrophoresis
fouling
electrophoresis
Electrodes

Keywords

  • β-agonists
  • Boron-doped diamond
  • Flow injection
  • Pulsed amperometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Karuwan, C., Mantim, T., Chaisuwan, P., Wilairat, P., Grudpan, K., Jittangprasert, P., ... Nacapricha, D. (2006). Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis. Sensors, 6(12), 1837-1850.

Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists : Application to flow injection for pharmaceutical analysis. / Karuwan, Chanpen; Mantim, Thitirat; Chaisuwan, Patcharin; Wilairat, Prapin; Grudpan, Kate; Jittangprasert, Piyada; Einaga, Yasuaki; Chailapakul, Orawon; Suntornsuk, Leena; Anurukvorakun, Oraphan; Nacapricha, Duangjai.

In: Sensors, Vol. 6, No. 12, 12.2006, p. 1837-1850.

Research output: Contribution to journalArticle

Karuwan, C, Mantim, T, Chaisuwan, P, Wilairat, P, Grudpan, K, Jittangprasert, P, Einaga, Y, Chailapakul, O, Suntornsuk, L, Anurukvorakun, O & Nacapricha, D 2006, 'Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis', Sensors, vol. 6, no. 12, pp. 1837-1850.
Karuwan C, Mantim T, Chaisuwan P, Wilairat P, Grudpan K, Jittangprasert P et al. Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis. Sensors. 2006 Dec;6(12):1837-1850.
Karuwan, Chanpen ; Mantim, Thitirat ; Chaisuwan, Patcharin ; Wilairat, Prapin ; Grudpan, Kate ; Jittangprasert, Piyada ; Einaga, Yasuaki ; Chailapakul, Orawon ; Suntornsuk, Leena ; Anurukvorakun, Oraphan ; Nacapricha, Duangjai. / Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists : Application to flow injection for pharmaceutical analysis. In: Sensors. 2006 ; Vol. 6, No. 12. pp. 1837-1850.
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