Pyripyropenes, novel inhibitors of acyl-coa: Cholesterol acyltransferase produced by aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

Young Kook Kim, Hiroshi Tomoda, Hiroyuki Nishida, Toshiaki Sunazuka, Rika Obata, Satoshi Omura

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, α-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalThe Journal of Antibiotics
Volume47
Issue number2
DOIs
Publication statusPublished - 1994 Jan 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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