Pyripyropenes, novel inhibitors of acyl-CoA: Cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

Y. K. Kim, H. Tomoda, H. Nishida, T. Sunazuka, R. Obata, S. Omura

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Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA :cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, α-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalJournal of Antibiotics
Volume47
Issue number2
Publication statusPublished - 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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