Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3

Yasuo Harada, Isao Ishii, Kiyohiko Hatake, Tadashi Kasahara

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Pyrvinium pamoate (PP), a classical anthelminthic, potently inhibited proliferation and STAT3 Tyr705 phosphorylation of human myeloma (U266B1 and PCM6)/erythroleukemia (HEL 92.1.7) cells. PCM6 cell proliferation was markedly impaired by STAT3 siRNA knockdown. PP inhibited ATP production/O 2 consumption in those three cells and mitochondrial respiratory complex (I+III, but not II+III) activity in mouse kidney mitochondrial fractions. PP inhibition of ATP production, STAT3 Tyr705 phosphorylation, and proliferation was absent in mitochondrial DNA-deficient HEL 92.1.7-ρ 0 cells. Moreover, PP acted synergistically with dexamethasone to inhibit PCM6 cell proliferation. In conclusion, we identified PP as a potential anticancer drug directed against mitochondrial respiratory complex I/STAT3.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalCancer Letters
Volume319
Issue number1
DOIs
Publication statusPublished - 2012 Jun 1
Externally publishedYes

Fingerprint

Electron Transport Complex I
Leukemia, Erythroblastic, Acute
Phosphorylation
Cell Proliferation
Mitochondrial DNA
Dexamethasone
Small Interfering RNA
Adenosine Triphosphate
pyrvinium
Kidney
Pharmaceutical Preparations

Keywords

  • Drug reprofiling
  • Mitochondrial respiratory chain
  • Myeloma
  • Pyrvinium pamoate
  • STAT3

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. / Harada, Yasuo; Ishii, Isao; Hatake, Kiyohiko; Kasahara, Tadashi.

In: Cancer Letters, Vol. 319, No. 1, 01.06.2012, p. 83-88.

Research output: Contribution to journalArticle

Harada, Yasuo ; Ishii, Isao ; Hatake, Kiyohiko ; Kasahara, Tadashi. / Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. In: Cancer Letters. 2012 ; Vol. 319, No. 1. pp. 83-88.
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