q-space MR imaging of gastric carcinoma ex vivo: Correlation with histopathologic findings

Ichiro Yamada, Keigo Hikishima, Naoyuki Miyasaka, Keiji Kato, Eisaku Ito, Kazuyuki Kojima, Tatsuyuki Kawano, Daisuke Kobayashi, Yoshinobu Eishi, Hideyuki Okano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to establish the feasibility of q-space imaging (QSI) as a method of assessing the depth of mural invasion, histologic grade, and the presence of lymph node metastasis in gastric carcinomas. Methods: A 7.0 Tesla MR imaging system was used to investigate 20 gastric specimens containing a carcinoma. QSI was performed by using the following parameters: 50–60 mm × 25–30 mm field of view, 2-mm section thickness, 256 × 128 matrix, 10 b values in the 0–7163 s/mm2 range, which corresponded to q values of 0–1026/cm, and motion-probing gradients perpendicular to the gastric wall. The MR images and the histopathologic findings were then compared. Results: The depth of tumor invasion of the gastric wall in all 20 carcinomas (100%) was established by using mean displacement, zero-displacement probability, and kurtosis maps. The QSI parameters were significantly correlated with the histologic grades of the gastric carcinomas (all P <0.001). The QSI parameters made it possible to differentiate between metastatic and nonmetastatic lymph nodes (all P = 0.001). Conclusion: Ex vivo QSI facilitates excellent diagnostics for evaluating gastric carcinomas in terms of mural invasion, histologic grade, and the presence of lymph node metastasis. Magn Reson Med 76:602–612, 2016.

Original languageEnglish
Pages (from-to)602-612
Number of pages11
JournalMagnetic Resonance in Medicine
Volume76
Issue number2
DOIs
Publication statusPublished - 2016 Aug 1

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Stomach
Carcinoma
Lymph Nodes
Neoplasm Metastasis
Neoplasms

Keywords

  • diffusion-weighted imaging
  • gastric carcinoma
  • MR imaging
  • q-space imaging
  • stomach

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

q-space MR imaging of gastric carcinoma ex vivo : Correlation with histopathologic findings. / Yamada, Ichiro; Hikishima, Keigo; Miyasaka, Naoyuki; Kato, Keiji; Ito, Eisaku; Kojima, Kazuyuki; Kawano, Tatsuyuki; Kobayashi, Daisuke; Eishi, Yoshinobu; Okano, Hideyuki.

In: Magnetic Resonance in Medicine, Vol. 76, No. 2, 01.08.2016, p. 602-612.

Research output: Contribution to journalArticle

Yamada, I, Hikishima, K, Miyasaka, N, Kato, K, Ito, E, Kojima, K, Kawano, T, Kobayashi, D, Eishi, Y & Okano, H 2016, 'q-space MR imaging of gastric carcinoma ex vivo: Correlation with histopathologic findings', Magnetic Resonance in Medicine, vol. 76, no. 2, pp. 602-612. https://doi.org/10.1002/mrm.25905
Yamada, Ichiro ; Hikishima, Keigo ; Miyasaka, Naoyuki ; Kato, Keiji ; Ito, Eisaku ; Kojima, Kazuyuki ; Kawano, Tatsuyuki ; Kobayashi, Daisuke ; Eishi, Yoshinobu ; Okano, Hideyuki. / q-space MR imaging of gastric carcinoma ex vivo : Correlation with histopathologic findings. In: Magnetic Resonance in Medicine. 2016 ; Vol. 76, No. 2. pp. 602-612.
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