Quality of life measures and health utility values among dry eye subgroups

DECS-J study group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: To determine whether quality of life (QOL) and health utility are affected to the same extent among dry eye (DE) patients with short tear film break-up time dry eye (TBUT-DE) with minimal clinical signs were as severe as aqueous-deficient dry eye (ADDE). Methods: A multicenter cross-sectional study was conducted among DE patients who visited one of 10 eye clinics in Japan. Among the 463 registered patients, this study involved 449 patients with DE who were aged 20 years or older. Ophthalmic examination findings were assessed, including tear film break-up time (TBUT), Schirmer I value, and keratoconjunctival staining score. QOL was evaluated with the Dry Eye-Related Quality-of-Life Score (DEQS; 0 [best], 100 [worst]) and health utility (1 [total health], 0 [worst]) with the Health Utilities Index Mark 3 (HUI-3); scores were stratified by DE subgroup. Results: Median (interquartile range) of DEQS and HUI-3 scores across all participants were 21.7 (10.0-40.0) and 0.82 (0.69-0.91), respectively. Median (interquartile range) DEQS and HUI-3 scores in the ADDE group were 23.3 (10.0-40.0) and 0.79 (0.69-0.88), respectively; those in the short TBUT-DE group were 23.3 (13.3-38.3) and 0.82 (0.74-0.92), respectively. There were no significant between-group differences in questionnaire scores. Among the ophthalmic examination findings, a weak significant correlation between TBUT, corneal staining score and keratoconjunctival staining score to DEQS; TBUT and Schirmer test values to HUI-3, were seen. Conclusions: The burden of short TBUT-DE on QOL as assessed by the DEQS and HUI-3 was as severe as that in ADDE. Our findings suggest that clinicians should be aware of the impact of short TBUT-DE on patients QOL and utility values.

Original languageEnglish
Article number170
JournalHealth and Quality of Life Outcomes
Volume16
Issue number1
DOIs
Publication statusPublished - 2018 Aug 31

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Quality of Life
Health
Tears
Staining and Labeling
Japan
Cross-Sectional Studies

Keywords

  • Cross-sectional study
  • Dry eye
  • Health utility assessment
  • Short tear film break-up time
  • Visual quality of life

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Quality of life measures and health utility values among dry eye subgroups. / DECS-J study group.

In: Health and Quality of Life Outcomes, Vol. 16, No. 1, 170, 31.08.2018.

Research output: Contribution to journalArticle

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title = "Quality of life measures and health utility values among dry eye subgroups",
abstract = "Background: To determine whether quality of life (QOL) and health utility are affected to the same extent among dry eye (DE) patients with short tear film break-up time dry eye (TBUT-DE) with minimal clinical signs were as severe as aqueous-deficient dry eye (ADDE). Methods: A multicenter cross-sectional study was conducted among DE patients who visited one of 10 eye clinics in Japan. Among the 463 registered patients, this study involved 449 patients with DE who were aged 20 years or older. Ophthalmic examination findings were assessed, including tear film break-up time (TBUT), Schirmer I value, and keratoconjunctival staining score. QOL was evaluated with the Dry Eye-Related Quality-of-Life Score (DEQS; 0 [best], 100 [worst]) and health utility (1 [total health], 0 [worst]) with the Health Utilities Index Mark 3 (HUI-3); scores were stratified by DE subgroup. Results: Median (interquartile range) of DEQS and HUI-3 scores across all participants were 21.7 (10.0-40.0) and 0.82 (0.69-0.91), respectively. Median (interquartile range) DEQS and HUI-3 scores in the ADDE group were 23.3 (10.0-40.0) and 0.79 (0.69-0.88), respectively; those in the short TBUT-DE group were 23.3 (13.3-38.3) and 0.82 (0.74-0.92), respectively. There were no significant between-group differences in questionnaire scores. Among the ophthalmic examination findings, a weak significant correlation between TBUT, corneal staining score and keratoconjunctival staining score to DEQS; TBUT and Schirmer test values to HUI-3, were seen. Conclusions: The burden of short TBUT-DE on QOL as assessed by the DEQS and HUI-3 was as severe as that in ADDE. Our findings suggest that clinicians should be aware of the impact of short TBUT-DE on patients QOL and utility values.",
keywords = "Cross-sectional study, Dry eye, Health utility assessment, Short tear film break-up time, Visual quality of life",
author = "{DECS-J study group} and Chika Shigeyasu and Masakazu Yamada and Motoko Kawashima and Kazuhisa Suwaki and Miki Uchino and Yoshimune Hiratsuka and Norihiko Yokoi and Kazuo Tsubota and Chika Shigeyasu and Masakazu Yamada and Motoko Kawashima and Kazuhisa Suwaki and Miki Uchino and Yoshimune Hiratsuka and Norihiko Yokoi and Kazuo Tsubota and Yoshitsugu Tagawa and Seika Den and Miki Iwasaki and Hiroshi Saito and Reiko Ishida and Aoi Komuro and Naoki Iwasaki and Harue Matsumoto and Tomoko Goto and Atsuko Kiyosawa",
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month = "8",
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doi = "10.1186/s12955-018-0999-3",
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TY - JOUR

T1 - Quality of life measures and health utility values among dry eye subgroups

AU - DECS-J study group

AU - Shigeyasu, Chika

AU - Yamada, Masakazu

AU - Kawashima, Motoko

AU - Suwaki, Kazuhisa

AU - Uchino, Miki

AU - Hiratsuka, Yoshimune

AU - Yokoi, Norihiko

AU - Tsubota, Kazuo

AU - Shigeyasu, Chika

AU - Yamada, Masakazu

AU - Kawashima, Motoko

AU - Suwaki, Kazuhisa

AU - Uchino, Miki

AU - Hiratsuka, Yoshimune

AU - Yokoi, Norihiko

AU - Tsubota, Kazuo

AU - Tagawa, Yoshitsugu

AU - Den, Seika

AU - Iwasaki, Miki

AU - Saito, Hiroshi

AU - Ishida, Reiko

AU - Komuro, Aoi

AU - Iwasaki, Naoki

AU - Matsumoto, Harue

AU - Goto, Tomoko

AU - Kiyosawa, Atsuko

PY - 2018/8/31

Y1 - 2018/8/31

N2 - Background: To determine whether quality of life (QOL) and health utility are affected to the same extent among dry eye (DE) patients with short tear film break-up time dry eye (TBUT-DE) with minimal clinical signs were as severe as aqueous-deficient dry eye (ADDE). Methods: A multicenter cross-sectional study was conducted among DE patients who visited one of 10 eye clinics in Japan. Among the 463 registered patients, this study involved 449 patients with DE who were aged 20 years or older. Ophthalmic examination findings were assessed, including tear film break-up time (TBUT), Schirmer I value, and keratoconjunctival staining score. QOL was evaluated with the Dry Eye-Related Quality-of-Life Score (DEQS; 0 [best], 100 [worst]) and health utility (1 [total health], 0 [worst]) with the Health Utilities Index Mark 3 (HUI-3); scores were stratified by DE subgroup. Results: Median (interquartile range) of DEQS and HUI-3 scores across all participants were 21.7 (10.0-40.0) and 0.82 (0.69-0.91), respectively. Median (interquartile range) DEQS and HUI-3 scores in the ADDE group were 23.3 (10.0-40.0) and 0.79 (0.69-0.88), respectively; those in the short TBUT-DE group were 23.3 (13.3-38.3) and 0.82 (0.74-0.92), respectively. There were no significant between-group differences in questionnaire scores. Among the ophthalmic examination findings, a weak significant correlation between TBUT, corneal staining score and keratoconjunctival staining score to DEQS; TBUT and Schirmer test values to HUI-3, were seen. Conclusions: The burden of short TBUT-DE on QOL as assessed by the DEQS and HUI-3 was as severe as that in ADDE. Our findings suggest that clinicians should be aware of the impact of short TBUT-DE on patients QOL and utility values.

AB - Background: To determine whether quality of life (QOL) and health utility are affected to the same extent among dry eye (DE) patients with short tear film break-up time dry eye (TBUT-DE) with minimal clinical signs were as severe as aqueous-deficient dry eye (ADDE). Methods: A multicenter cross-sectional study was conducted among DE patients who visited one of 10 eye clinics in Japan. Among the 463 registered patients, this study involved 449 patients with DE who were aged 20 years or older. Ophthalmic examination findings were assessed, including tear film break-up time (TBUT), Schirmer I value, and keratoconjunctival staining score. QOL was evaluated with the Dry Eye-Related Quality-of-Life Score (DEQS; 0 [best], 100 [worst]) and health utility (1 [total health], 0 [worst]) with the Health Utilities Index Mark 3 (HUI-3); scores were stratified by DE subgroup. Results: Median (interquartile range) of DEQS and HUI-3 scores across all participants were 21.7 (10.0-40.0) and 0.82 (0.69-0.91), respectively. Median (interquartile range) DEQS and HUI-3 scores in the ADDE group were 23.3 (10.0-40.0) and 0.79 (0.69-0.88), respectively; those in the short TBUT-DE group were 23.3 (13.3-38.3) and 0.82 (0.74-0.92), respectively. There were no significant between-group differences in questionnaire scores. Among the ophthalmic examination findings, a weak significant correlation between TBUT, corneal staining score and keratoconjunctival staining score to DEQS; TBUT and Schirmer test values to HUI-3, were seen. Conclusions: The burden of short TBUT-DE on QOL as assessed by the DEQS and HUI-3 was as severe as that in ADDE. Our findings suggest that clinicians should be aware of the impact of short TBUT-DE on patients QOL and utility values.

KW - Cross-sectional study

KW - Dry eye

KW - Health utility assessment

KW - Short tear film break-up time

KW - Visual quality of life

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U2 - 10.1186/s12955-018-0999-3

DO - 10.1186/s12955-018-0999-3

M3 - Article

VL - 16

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

SN - 1477-7525

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M1 - 170

ER -