Quantifying periodicity in omics data

Cornelia Amariei, Masaru Tomita, Douglas B. Murray

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Oscillations play a significant role in biological systems, with many examples in the fast, ultradian, circadian, circalunar, and yearly time domains. However, determining periodicity in such data can be problematic. There are a number of computational methods to identify the periodic components in large datasets, such as signal-to-noise based Fourier decomposition, Fisher's g-test and autocorrelation. However, the available methods assume a sinusoidal model and do not attempt to quantify the waveform shape and the presence of multiple periodicities, which provide vital clues in determining the underlying dynamics. Here, we developed a Fourier based measure that generates a de-noised waveform from multiple significant frequencies. This waveform is then correlated with the raw data from the respiratory oscillation found in yeast, to provide oscillation statistics including waveform metrics and multi-periods. The method is compared and contrasted to commonly used statistics. Moreover, we show the utility of the program in the analysis of noisy datasets and other high-throughput analyses, such as metabolomics and flow cytometry, respectively.

Original languageEnglish
Article number40
JournalFrontiers in Cell and Developmental Biology
Volume2
Issue numberAUG
DOIs
Publication statusPublished - 2014 Aug 19

Fingerprint

Periodicity
Metabolomics
Noise
Flow Cytometry
Yeasts
Datasets

Keywords

  • Flow cytometry
  • Metabolic oscillation
  • Metabolomics
  • Periodicity tests
  • Waveform analysis

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Quantifying periodicity in omics data. / Amariei, Cornelia; Tomita, Masaru; Murray, Douglas B.

In: Frontiers in Cell and Developmental Biology, Vol. 2, No. AUG, 40, 19.08.2014.

Research output: Contribution to journalArticle

Amariei, Cornelia ; Tomita, Masaru ; Murray, Douglas B. / Quantifying periodicity in omics data. In: Frontiers in Cell and Developmental Biology. 2014 ; Vol. 2, No. AUG.
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