Quantitative Assessment of Bone Metastasis in Prostate Cancer Using Synthetic Magnetic Resonance Imaging

Yuki Arita, Taro Takahara, Soichiro Yoshida, Thomas C. Kwee, Shugo Yajima, Chikako Ishii, Ryota Ishii, Shigeo Okuda, Masahiro Jinzaki, Yasuhisa Fujii

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The aims of this study were to evaluate the feasibility of quantitative synthetic magnetic resonance imaging (SyMRI) for characterizing bone lesions in prostate cancer and to discriminate viable progressive osteoblastic bone metastasis from nonviable bone metastases with treatment-induced sclerosis during the treatment course. MATERIALS AND METHODS: This institutional review board-approved prospective study included 96 consecutive prostate cancer patients who underwent whole-body MRI including diffusion-weighted imaging at the time of staging at diagnosis or starting a new line of anticancer treatment. Additional synthetic MRI of the lumbosacral spine, pelvis, and proximal femurs was performed. A region of interest of 1.0 cm in diameter was set in each bone lesion by 2 independent readers who were blinded to bone lesions' diagnosis. Differences in SyMRI variables between the different bone lesions were compared with the Wilcoxon rank sum test, and associations of SyMRI variables with active disease were analyzed with logistic regression analysis. Performance of T1, T2, and proton density (PD) for diagnosing active disease was assessed using the area under the receiver operating characteristic curve. RESULTS: Ninety-three bone lesions were eligible for analysis. The PD values of active (viable) bone metastatic lesions were significantly higher than those of inactive (nonviable) bone metastatic lesions without sclerosis and those of red bone marrow (P < 0.001 for both readers). The PD values of inactive bone metastatic lesions with sclerosis were significantly lower than those of inactive bone metastatic lesions without sclerosis and red bone marrow (P < 0.001 for both readers). The PD value proved to be an independent significant indicator (P < 0.001) for differentiating bone lesions. The areas under the curve of T1/T2/PD for identifying active disease were 0.81/0.69/0.93 for reader 1 and 0.78/0.70/0.92 for reader 2, respectively. CONCLUSIONS: Signal quantification on SyMRI provides objective assessment of bone lesions in the lower trunk. The PD value can be useful to determine the viability of bone metastases in prostate cancer.

Original languageEnglish
Pages (from-to)638-644
Number of pages7
JournalInvestigative radiology
Volume54
Issue number10
DOIs
Publication statusPublished - 2019 Oct 1

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Prostatic Neoplasms
Magnetic Resonance Imaging
Neoplasm Metastasis
Bone and Bones
Protons
Sclerosis
Bone Marrow
Nonparametric Statistics
Diffusion Magnetic Resonance Imaging
Research Ethics Committees
Pelvis
ROC Curve
Femur
Area Under Curve
Spine
Therapeutics
Logistic Models
Regression Analysis
Prospective Studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Arita, Y., Takahara, T., Yoshida, S., Kwee, T. C., Yajima, S., Ishii, C., ... Fujii, Y. (2019). Quantitative Assessment of Bone Metastasis in Prostate Cancer Using Synthetic Magnetic Resonance Imaging. Investigative radiology, 54(10), 638-644. https://doi.org/10.1097/RLI.0000000000000579

Quantitative Assessment of Bone Metastasis in Prostate Cancer Using Synthetic Magnetic Resonance Imaging. / Arita, Yuki; Takahara, Taro; Yoshida, Soichiro; Kwee, Thomas C.; Yajima, Shugo; Ishii, Chikako; Ishii, Ryota; Okuda, Shigeo; Jinzaki, Masahiro; Fujii, Yasuhisa.

In: Investigative radiology, Vol. 54, No. 10, 01.10.2019, p. 638-644.

Research output: Contribution to journalArticle

Arita, Yuki ; Takahara, Taro ; Yoshida, Soichiro ; Kwee, Thomas C. ; Yajima, Shugo ; Ishii, Chikako ; Ishii, Ryota ; Okuda, Shigeo ; Jinzaki, Masahiro ; Fujii, Yasuhisa. / Quantitative Assessment of Bone Metastasis in Prostate Cancer Using Synthetic Magnetic Resonance Imaging. In: Investigative radiology. 2019 ; Vol. 54, No. 10. pp. 638-644.
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AU - Yoshida, Soichiro

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AU - Yajima, Shugo

AU - Ishii, Chikako

AU - Ishii, Ryota

AU - Okuda, Shigeo

AU - Jinzaki, Masahiro

AU - Fujii, Yasuhisa

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AB - OBJECTIVES: The aims of this study were to evaluate the feasibility of quantitative synthetic magnetic resonance imaging (SyMRI) for characterizing bone lesions in prostate cancer and to discriminate viable progressive osteoblastic bone metastasis from nonviable bone metastases with treatment-induced sclerosis during the treatment course. MATERIALS AND METHODS: This institutional review board-approved prospective study included 96 consecutive prostate cancer patients who underwent whole-body MRI including diffusion-weighted imaging at the time of staging at diagnosis or starting a new line of anticancer treatment. Additional synthetic MRI of the lumbosacral spine, pelvis, and proximal femurs was performed. A region of interest of 1.0 cm in diameter was set in each bone lesion by 2 independent readers who were blinded to bone lesions' diagnosis. Differences in SyMRI variables between the different bone lesions were compared with the Wilcoxon rank sum test, and associations of SyMRI variables with active disease were analyzed with logistic regression analysis. Performance of T1, T2, and proton density (PD) for diagnosing active disease was assessed using the area under the receiver operating characteristic curve. RESULTS: Ninety-three bone lesions were eligible for analysis. The PD values of active (viable) bone metastatic lesions were significantly higher than those of inactive (nonviable) bone metastatic lesions without sclerosis and those of red bone marrow (P < 0.001 for both readers). The PD values of inactive bone metastatic lesions with sclerosis were significantly lower than those of inactive bone metastatic lesions without sclerosis and red bone marrow (P < 0.001 for both readers). The PD value proved to be an independent significant indicator (P < 0.001) for differentiating bone lesions. The areas under the curve of T1/T2/PD for identifying active disease were 0.81/0.69/0.93 for reader 1 and 0.78/0.70/0.92 for reader 2, respectively. CONCLUSIONS: Signal quantification on SyMRI provides objective assessment of bone lesions in the lower trunk. The PD value can be useful to determine the viability of bone metastases in prostate cancer.

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