Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease

Takanori Asakura, Yoshitake Yamada, Shoji Suzuki, Ho Namkoong, Satoshi Okamori, Tatsuya Kusumoto, Yuki Niijima, Akihiko Ozaki, Masahiro Hashimoto, Kazuma Yagi, Hirofumi Kamata, Yohei Funatsu, Makoto Ishii, Masahiro Jinzaki, Tomoko Betsuyaku, Naoki Hasegawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and objective: No reports exist regarding skeletal muscle involvement in patients with Mycobacterium avium complex lung disease (MAC-LD). The cross-sectional area of the erector spinae muscles (ESMCSA) reflects physical activity and can be assessed by computed tomography (CT). We investigated the relationship between ESMCSA and physiological parameters and prognosis in MAC-LD patients. Material and methods: In this prospective observational study, the ESMCSA was measured on single-slice axial CT images. MAC-LD patients and sex- and age-matched controls (non-MAC-LD participants) were evaluated. We evaluated the relationship between the ESMCSA and physiological parameters and prognosis. Results: A total of 260 patients (209 female; median age, 69 years; 190 with nodular/bronchiectatic disease; 74 with cavitary lesions) were enrolled. The ESMCSA was not different between MAC-LD patients and controls. In MAC-LD patients, the ESMCSA was significantly associated with age, body mass index (BMI), pulmonary function, CT severity, and health-related quality of life (HRQL). Multivariate Cox proportional hazards analyses revealed that an ESMCSA < −1 standard derivation (hazards ratio [HR], 2.76; P = 0.047) was significantly associated with all-cause mortality, along with BMI < 18.5 kg/m2 (HR, 3.67; P = 0.02) and presence of cavitary lesions (HR, 5.84; P = 0.001). However, the ESMCSA was not significantly associated with all-cause mortality when current treatment status, % predicted functional vital capacity, and forced expiratory volume in 1 s were added to the analyses. Conclusions: Although the prognostic impact was limited, ESMCSA was significantly associated with HRQL and prognostic physiological parameters, such as BMI and pulmonary function.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalRespiratory Medicine
Volume145
DOIs
Publication statusPublished - 2018 Dec 1

Fingerprint

Mycobacterium avium Complex
Lung Diseases
Muscles
Body Mass Index
Tomography
Quality of Life
Lung
Mortality
Vital Capacity
Forced Expiratory Volume
Observational Studies
Skeletal Muscle
Prospective Studies
Exercise

Keywords

  • Computed tomography
  • Mycobacterium avium complex (MAC)
  • Nontuberculous mycobacteria (NTM)
  • Respiratory function tests
  • St. George's respiratory questionnaire (SGRQ)
  • The 36-Item short-form health survey (SF-36)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease. / Asakura, Takanori; Yamada, Yoshitake; Suzuki, Shoji; Namkoong, Ho; Okamori, Satoshi; Kusumoto, Tatsuya; Niijima, Yuki; Ozaki, Akihiko; Hashimoto, Masahiro; Yagi, Kazuma; Kamata, Hirofumi; Funatsu, Yohei; Ishii, Makoto; Jinzaki, Masahiro; Betsuyaku, Tomoko; Hasegawa, Naoki.

In: Respiratory Medicine, Vol. 145, 01.12.2018, p. 66-72.

Research output: Contribution to journalArticle

Asakura, Takanori ; Yamada, Yoshitake ; Suzuki, Shoji ; Namkoong, Ho ; Okamori, Satoshi ; Kusumoto, Tatsuya ; Niijima, Yuki ; Ozaki, Akihiko ; Hashimoto, Masahiro ; Yagi, Kazuma ; Kamata, Hirofumi ; Funatsu, Yohei ; Ishii, Makoto ; Jinzaki, Masahiro ; Betsuyaku, Tomoko ; Hasegawa, Naoki. / Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease. In: Respiratory Medicine. 2018 ; Vol. 145. pp. 66-72.
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abstract = "Background and objective: No reports exist regarding skeletal muscle involvement in patients with Mycobacterium avium complex lung disease (MAC-LD). The cross-sectional area of the erector spinae muscles (ESMCSA) reflects physical activity and can be assessed by computed tomography (CT). We investigated the relationship between ESMCSA and physiological parameters and prognosis in MAC-LD patients. Material and methods: In this prospective observational study, the ESMCSA was measured on single-slice axial CT images. MAC-LD patients and sex- and age-matched controls (non-MAC-LD participants) were evaluated. We evaluated the relationship between the ESMCSA and physiological parameters and prognosis. Results: A total of 260 patients (209 female; median age, 69 years; 190 with nodular/bronchiectatic disease; 74 with cavitary lesions) were enrolled. The ESMCSA was not different between MAC-LD patients and controls. In MAC-LD patients, the ESMCSA was significantly associated with age, body mass index (BMI), pulmonary function, CT severity, and health-related quality of life (HRQL). Multivariate Cox proportional hazards analyses revealed that an ESMCSA < −1 standard derivation (hazards ratio [HR], 2.76; P = 0.047) was significantly associated with all-cause mortality, along with BMI < 18.5 kg/m2 (HR, 3.67; P = 0.02) and presence of cavitary lesions (HR, 5.84; P = 0.001). However, the ESMCSA was not significantly associated with all-cause mortality when current treatment status, {\%} predicted functional vital capacity, and forced expiratory volume in 1 s were added to the analyses. Conclusions: Although the prognostic impact was limited, ESMCSA was significantly associated with HRQL and prognostic physiological parameters, such as BMI and pulmonary function.",
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T1 - Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease

AU - Asakura, Takanori

AU - Yamada, Yoshitake

AU - Suzuki, Shoji

AU - Namkoong, Ho

AU - Okamori, Satoshi

AU - Kusumoto, Tatsuya

AU - Niijima, Yuki

AU - Ozaki, Akihiko

AU - Hashimoto, Masahiro

AU - Yagi, Kazuma

AU - Kamata, Hirofumi

AU - Funatsu, Yohei

AU - Ishii, Makoto

AU - Jinzaki, Masahiro

AU - Betsuyaku, Tomoko

AU - Hasegawa, Naoki

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background and objective: No reports exist regarding skeletal muscle involvement in patients with Mycobacterium avium complex lung disease (MAC-LD). The cross-sectional area of the erector spinae muscles (ESMCSA) reflects physical activity and can be assessed by computed tomography (CT). We investigated the relationship between ESMCSA and physiological parameters and prognosis in MAC-LD patients. Material and methods: In this prospective observational study, the ESMCSA was measured on single-slice axial CT images. MAC-LD patients and sex- and age-matched controls (non-MAC-LD participants) were evaluated. We evaluated the relationship between the ESMCSA and physiological parameters and prognosis. Results: A total of 260 patients (209 female; median age, 69 years; 190 with nodular/bronchiectatic disease; 74 with cavitary lesions) were enrolled. The ESMCSA was not different between MAC-LD patients and controls. In MAC-LD patients, the ESMCSA was significantly associated with age, body mass index (BMI), pulmonary function, CT severity, and health-related quality of life (HRQL). Multivariate Cox proportional hazards analyses revealed that an ESMCSA < −1 standard derivation (hazards ratio [HR], 2.76; P = 0.047) was significantly associated with all-cause mortality, along with BMI < 18.5 kg/m2 (HR, 3.67; P = 0.02) and presence of cavitary lesions (HR, 5.84; P = 0.001). However, the ESMCSA was not significantly associated with all-cause mortality when current treatment status, % predicted functional vital capacity, and forced expiratory volume in 1 s were added to the analyses. Conclusions: Although the prognostic impact was limited, ESMCSA was significantly associated with HRQL and prognostic physiological parameters, such as BMI and pulmonary function.

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KW - Mycobacterium avium complex (MAC)

KW - Nontuberculous mycobacteria (NTM)

KW - Respiratory function tests

KW - St. George's respiratory questionnaire (SGRQ)

KW - The 36-Item short-form health survey (SF-36)

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