Quantitative evaluation of deep and shallow tissue layers' contribution to fNIRS signal using multi-distance optodes and independent component analysis

Tsukasa Funane, Hirokazu Atsumori, Takusige Katura, Akiko N. Obata, Hiroki Sato, Yukari Tanikawa, Eiji Okada, Masashi Kiguchi

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

To quantify the effect of absorption changes in the deep tissue (cerebral) and shallow tissue (scalp, skin) layers on functional near-infrared spectroscopy (fNIRS) signals, a method using multi-distance (MD) optodes and independent component analysis (ICA), referred to as the MD-ICA method, is proposed. In previous studies, when the signal from the shallow tissue layer (shallow signal) needs to be eliminated, it was often assumed that the shallow signal had no correlation with the signal from the deep tissue layer (deep signal). In this study, no relationship between the waveforms of deep and shallow signals is assumed, and instead, it is assumed that both signals are linear combinations of multiple signal sources, which allows the inclusion of a "shared component" (such as systemic signals) that is contained in both layers. The method also assumes that the partial optical path length of the shallow layer does not change, whereas that of the deep layer linearly increases along with the increase of the source-detector (S-D) distance. Deep- and shallow-layer contribution ratios of each independent component (IC) are calculated using the dependence of the weight of each IC on the S-D distance. Reconstruction of deep- and shallow-layer signals are performed by the sum of ICs weighted by the deep and shallow contribution ratio. Experimental validation of the principle of this technique was conducted using a dynamic phantom with two absorbing layers. Results showed that our method is effective for evaluating deep-layer contributions even if there are high correlations between deep and shallow signals. Next, we applied the method to fNIRS signals obtained on a human head with 5-, 15-, and 30-mm S-D distances during a verbal fluency task, a verbal working memory task (prefrontal area), a finger tapping task (motor area), and a tetrametric visual checker-board task (occipital area) and then estimated the deep-layer contribution ratio. To evaluate the signal separation performance of our method, we used the correlation coefficients of a laser-Doppler flowmetry (LDF) signal and a nearest 5-mm S-D distance channel signal with the shallow signal. We demonstrated that the shallow signals have a higher temporal correlation with the LDF signals and with the 5-mm S-D distance channel than the deep signals. These results show the MD-ICA method can discriminate between deep and shallow signals.

Original languageEnglish
Pages (from-to)150-165
Number of pages16
JournalNeuroImage
Volume85
DOIs
Publication statusPublished - 2014 Jan 15

Fingerprint

Near-Infrared Spectroscopy
Laser-Doppler Flowmetry
Motor Cortex
Scalp
Short-Term Memory
Fingers
Head
Weights and Measures
Skin

Keywords

  • Brain activity measurement
  • Functional near-infrared spectroscopy (fNIRS)
  • Independent component analysis (ICA)
  • Multi-distance optodes
  • Scalp (skin) blood flow
  • Verbal fluency task (VFT)

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Quantitative evaluation of deep and shallow tissue layers' contribution to fNIRS signal using multi-distance optodes and independent component analysis. / Funane, Tsukasa; Atsumori, Hirokazu; Katura, Takusige; Obata, Akiko N.; Sato, Hiroki; Tanikawa, Yukari; Okada, Eiji; Kiguchi, Masashi.

In: NeuroImage, Vol. 85, 15.01.2014, p. 150-165.

Research output: Contribution to journalArticle

Funane, Tsukasa ; Atsumori, Hirokazu ; Katura, Takusige ; Obata, Akiko N. ; Sato, Hiroki ; Tanikawa, Yukari ; Okada, Eiji ; Kiguchi, Masashi. / Quantitative evaluation of deep and shallow tissue layers' contribution to fNIRS signal using multi-distance optodes and independent component analysis. In: NeuroImage. 2014 ; Vol. 85. pp. 150-165.
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