Quantitative evaluation of tear meniscus height from fluorescein photographs

Masataka Kawai, Masakazu Yamada, Motoko Kawashima, Makoto Inoue, Eiki Goto, Yukihiko Mashima, Kazuo Tsubota

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

PURPOSE: To describe a method of quantifying the tear meniscus height (TMH) and using these values to diagnose patients with dry eye. METHODS: Thirty-eight eyes of 19 healthy subjects and 14 patients diagnosed with dry eye were studied. Each eye received 2 μL of 1% fluorescein-sodium solution in the conjunctival sac, and digital photographs were taken of the external surface of the eye with a fundus camera. The tear meniscus was extracted from the digitalized image and used to measure the TMH with NIH image software. The correlation between the mean TMH and Schirmer test values or cotton-thread test values was evaluated. RESULTS: The means of the upper and lower TMH in healthy subjects were 0.22 ± 0.06 and 0.24 ± 0.08 mm, respectively. The comparable values in patients with dry eye were 0.17 ± 0.04 and 0.17 ± 0.07 mm (upper TMS, P = 0.01; lower TMH, P = 0.04; unpaired t test). A significant correlation was found between the TMH and Schirmer test values (r = 0.72, P = 0.01) but not with cotton-thread test values. CONCLUSIONS: Fluorescein photographs of the eye can be used to quantify the upper and lower TMH separately and simultaneously without specialized equipment. This technique can be used for the diagnosis of dry eye.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalCornea
Volume26
Issue number4
DOIs
Publication statusPublished - 2007 May

Fingerprint

Fluorescein
Tears
Healthy Volunteers
Lacrimal Apparatus
Meniscus
Software
Equipment and Supplies

Keywords

  • Dry eye
  • Fluorescein
  • Fundus camera
  • Tear meniscus

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kawai, M., Yamada, M., Kawashima, M., Inoue, M., Goto, E., Mashima, Y., & Tsubota, K. (2007). Quantitative evaluation of tear meniscus height from fluorescein photographs. Cornea, 26(4), 403-406. https://doi.org/10.1097/ICO.0b013e318033c242

Quantitative evaluation of tear meniscus height from fluorescein photographs. / Kawai, Masataka; Yamada, Masakazu; Kawashima, Motoko; Inoue, Makoto; Goto, Eiki; Mashima, Yukihiko; Tsubota, Kazuo.

In: Cornea, Vol. 26, No. 4, 05.2007, p. 403-406.

Research output: Contribution to journalArticle

Kawai, M, Yamada, M, Kawashima, M, Inoue, M, Goto, E, Mashima, Y & Tsubota, K 2007, 'Quantitative evaluation of tear meniscus height from fluorescein photographs', Cornea, vol. 26, no. 4, pp. 403-406. https://doi.org/10.1097/ICO.0b013e318033c242
Kawai M, Yamada M, Kawashima M, Inoue M, Goto E, Mashima Y et al. Quantitative evaluation of tear meniscus height from fluorescein photographs. Cornea. 2007 May;26(4):403-406. https://doi.org/10.1097/ICO.0b013e318033c242
Kawai, Masataka ; Yamada, Masakazu ; Kawashima, Motoko ; Inoue, Makoto ; Goto, Eiki ; Mashima, Yukihiko ; Tsubota, Kazuo. / Quantitative evaluation of tear meniscus height from fluorescein photographs. In: Cornea. 2007 ; Vol. 26, No. 4. pp. 403-406.
@article{10636e969ebf42b8aefaca4642a75804,
title = "Quantitative evaluation of tear meniscus height from fluorescein photographs",
abstract = "PURPOSE: To describe a method of quantifying the tear meniscus height (TMH) and using these values to diagnose patients with dry eye. METHODS: Thirty-eight eyes of 19 healthy subjects and 14 patients diagnosed with dry eye were studied. Each eye received 2 μL of 1{\%} fluorescein-sodium solution in the conjunctival sac, and digital photographs were taken of the external surface of the eye with a fundus camera. The tear meniscus was extracted from the digitalized image and used to measure the TMH with NIH image software. The correlation between the mean TMH and Schirmer test values or cotton-thread test values was evaluated. RESULTS: The means of the upper and lower TMH in healthy subjects were 0.22 ± 0.06 and 0.24 ± 0.08 mm, respectively. The comparable values in patients with dry eye were 0.17 ± 0.04 and 0.17 ± 0.07 mm (upper TMS, P = 0.01; lower TMH, P = 0.04; unpaired t test). A significant correlation was found between the TMH and Schirmer test values (r = 0.72, P = 0.01) but not with cotton-thread test values. CONCLUSIONS: Fluorescein photographs of the eye can be used to quantify the upper and lower TMH separately and simultaneously without specialized equipment. This technique can be used for the diagnosis of dry eye.",
keywords = "Dry eye, Fluorescein, Fundus camera, Tear meniscus",
author = "Masataka Kawai and Masakazu Yamada and Motoko Kawashima and Makoto Inoue and Eiki Goto and Yukihiko Mashima and Kazuo Tsubota",
year = "2007",
month = "5",
doi = "10.1097/ICO.0b013e318033c242",
language = "English",
volume = "26",
pages = "403--406",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Quantitative evaluation of tear meniscus height from fluorescein photographs

AU - Kawai, Masataka

AU - Yamada, Masakazu

AU - Kawashima, Motoko

AU - Inoue, Makoto

AU - Goto, Eiki

AU - Mashima, Yukihiko

AU - Tsubota, Kazuo

PY - 2007/5

Y1 - 2007/5

N2 - PURPOSE: To describe a method of quantifying the tear meniscus height (TMH) and using these values to diagnose patients with dry eye. METHODS: Thirty-eight eyes of 19 healthy subjects and 14 patients diagnosed with dry eye were studied. Each eye received 2 μL of 1% fluorescein-sodium solution in the conjunctival sac, and digital photographs were taken of the external surface of the eye with a fundus camera. The tear meniscus was extracted from the digitalized image and used to measure the TMH with NIH image software. The correlation between the mean TMH and Schirmer test values or cotton-thread test values was evaluated. RESULTS: The means of the upper and lower TMH in healthy subjects were 0.22 ± 0.06 and 0.24 ± 0.08 mm, respectively. The comparable values in patients with dry eye were 0.17 ± 0.04 and 0.17 ± 0.07 mm (upper TMS, P = 0.01; lower TMH, P = 0.04; unpaired t test). A significant correlation was found between the TMH and Schirmer test values (r = 0.72, P = 0.01) but not with cotton-thread test values. CONCLUSIONS: Fluorescein photographs of the eye can be used to quantify the upper and lower TMH separately and simultaneously without specialized equipment. This technique can be used for the diagnosis of dry eye.

AB - PURPOSE: To describe a method of quantifying the tear meniscus height (TMH) and using these values to diagnose patients with dry eye. METHODS: Thirty-eight eyes of 19 healthy subjects and 14 patients diagnosed with dry eye were studied. Each eye received 2 μL of 1% fluorescein-sodium solution in the conjunctival sac, and digital photographs were taken of the external surface of the eye with a fundus camera. The tear meniscus was extracted from the digitalized image and used to measure the TMH with NIH image software. The correlation between the mean TMH and Schirmer test values or cotton-thread test values was evaluated. RESULTS: The means of the upper and lower TMH in healthy subjects were 0.22 ± 0.06 and 0.24 ± 0.08 mm, respectively. The comparable values in patients with dry eye were 0.17 ± 0.04 and 0.17 ± 0.07 mm (upper TMS, P = 0.01; lower TMH, P = 0.04; unpaired t test). A significant correlation was found between the TMH and Schirmer test values (r = 0.72, P = 0.01) but not with cotton-thread test values. CONCLUSIONS: Fluorescein photographs of the eye can be used to quantify the upper and lower TMH separately and simultaneously without specialized equipment. This technique can be used for the diagnosis of dry eye.

KW - Dry eye

KW - Fluorescein

KW - Fundus camera

KW - Tear meniscus

UR - http://www.scopus.com/inward/record.url?scp=34247620226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247620226&partnerID=8YFLogxK

U2 - 10.1097/ICO.0b013e318033c242

DO - 10.1097/ICO.0b013e318033c242

M3 - Article

VL - 26

SP - 403

EP - 406

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 4

ER -