Quantitative evaluation of the regional dynamic function of hepatocytes after living donor liver transplantation using99mTc-GSA: A preliminary report

Yasuharu Ohno, Haruo Ishida, Akira Hayashi, Shoichiro Kamagata, Seiichi Hirobe, Yasushi Fuchimoto, Katsumi Ishii

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Abstract

In this study, we attempted to evaluate the dynamic function of graft livers after a living donor liver transplantation (LDLT) using technetium-99m-galactosyl-human serum albumin (99mTc-GSA) scintigraphy. We performed 99mTc-GSA scintigraphy 24 times in a total of 15 pediatric patients following LDLT. The age at examination (mean±standard deviation) was 7.3±5.54 years. The median interval between the examination and LDLT was 42 months. We converted the time activity curve for the graft to a horizontal mirror image curve and calculated the mean transit time (MTT) and depicted the functional image. The whole graft MTT showed a significant correlation with the receptor index (r=-0.528, p= 0.014), total bilirubin (r=0.470, p=0.032) and cholinesterase (r=-0.641, p<0.014), and a marginally significant correlation with the clearance index (r=0.424, p =0.056). The functional image was quite useful for making a visual evaluation of the regional dynamic distribution of Tc-GSA in the graft. We thus consider this modality a valuable adjunct for evaluating the regional deterioration of the dynamic function of the liver following liver transplantation.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalActa Medica Nagasakiensia
Volume49
Issue number4
Publication statusPublished - 2004 Dec 1

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Keywords

  • Asialoglycoprotein receptor scintigraphy
  • Dynamic function of the liver
  • Liver transplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ohno, Y., Ishida, H., Hayashi, A., Kamagata, S., Hirobe, S., Fuchimoto, Y., & Ishii, K. (2004). Quantitative evaluation of the regional dynamic function of hepatocytes after living donor liver transplantation using99mTc-GSA: A preliminary report. Acta Medica Nagasakiensia, 49(4), 137-141.