Quantitative evaluation of the tracer distribution in dopamine transporter SPECT for objective interpretation

Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yoshitake Yamada, Masahiro Hashimoto, Yuji Ogata, Yoji Matsusaka, Mari Katagiri, Kazunari Itoh, Takashi Osada, Daisuke Ito, Hajime Tabuchi, Masahiro Jinzaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Quantification of the tracer distribution would add objectivity to the visual assessments of dopamine transporter (DAT) single photon emission computed tomography (SPECT) data. Our study aimed to evaluate the diagnostic utility of fractal dimension (FD) as a quantitative indicator of tracer distribution and compared with the conventional quantitative value: specific binding ratio (SBR). We also evaluated the utility of the combined index SBR/FD (SBR divided by FD). Materials and methods: We conducted both clinical and phantom studies. In the clinical study, 150 patients including 110 patients with Parkinsonian syndrome (PS) and 40 without PS were enrolled. In the phantom study, we used a striatal phantom with the striatum chamber divided into two spaces, representing the caudate nucleus and putamen. The SBR, FD, and SBR/FD were calculated and compared between datasets for evaluating the diagnostic utility. Mann–Whitney test and receiver-operating characteristics (ROC) analysis were used for analysis. Results: ROC analysis revealed that the FD value had high diagnostic performance [the areas under the curve (AUC) = 0.943] and the combined use of SBR and FD (SBR/FD) delivered better results than the SBR alone (AUC, 0.964 vs 0.899; p < 0.001). The sensitivity, specificity, and accuracy, respectively, were 79.1, 85.0, and 80.7% with SBR, 84.5, 97.5, and 88.0% with FD, and 92.7, 87.5, and 91.3% with SBR/FD. Conclusion: Our results confirmed that the FD value is a useful diagnostic index, which reflects the tracer distribution in DAT SPECT images. The combined use of SBR and FD was more useful than either used alone.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAnnals of Nuclear Medicine
DOIs
Publication statusAccepted/In press - 2018 Apr 13

Fingerprint

Fractals
Dopamine Plasma Membrane Transport Proteins
Single-Photon Emission-Computed Tomography
Parkinsonian Disorders
ROC Curve
Area Under Curve
Corpus Striatum
Caudate Nucleus
Putamen

Keywords

  • I-FP-CIT
  • I-Ioflupane
  • DAT
  • Fractal analysis
  • Fractal dimension

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative evaluation of the tracer distribution in dopamine transporter SPECT for objective interpretation. / Iwabuchi, Yu; Nakahara, Tadaki; Kameyama, Masashi; Yamada, Yoshitake; Hashimoto, Masahiro; Ogata, Yuji; Matsusaka, Yoji; Katagiri, Mari; Itoh, Kazunari; Osada, Takashi; Ito, Daisuke; Tabuchi, Hajime; Jinzaki, Masahiro.

In: Annals of Nuclear Medicine, 13.04.2018, p. 1-9.

Research output: Contribution to journalArticle

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abstract = "Purpose: Quantification of the tracer distribution would add objectivity to the visual assessments of dopamine transporter (DAT) single photon emission computed tomography (SPECT) data. Our study aimed to evaluate the diagnostic utility of fractal dimension (FD) as a quantitative indicator of tracer distribution and compared with the conventional quantitative value: specific binding ratio (SBR). We also evaluated the utility of the combined index SBR/FD (SBR divided by FD). Materials and methods: We conducted both clinical and phantom studies. In the clinical study, 150 patients including 110 patients with Parkinsonian syndrome (PS) and 40 without PS were enrolled. In the phantom study, we used a striatal phantom with the striatum chamber divided into two spaces, representing the caudate nucleus and putamen. The SBR, FD, and SBR/FD were calculated and compared between datasets for evaluating the diagnostic utility. Mann–Whitney test and receiver-operating characteristics (ROC) analysis were used for analysis. Results: ROC analysis revealed that the FD value had high diagnostic performance [the areas under the curve (AUC) = 0.943] and the combined use of SBR and FD (SBR/FD) delivered better results than the SBR alone (AUC, 0.964 vs 0.899; p < 0.001). The sensitivity, specificity, and accuracy, respectively, were 79.1, 85.0, and 80.7{\%} with SBR, 84.5, 97.5, and 88.0{\%} with FD, and 92.7, 87.5, and 91.3{\%} with SBR/FD. Conclusion: Our results confirmed that the FD value is a useful diagnostic index, which reflects the tracer distribution in DAT SPECT images. The combined use of SBR and FD was more useful than either used alone.",
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AU - Hashimoto, Masahiro

AU - Ogata, Yuji

AU - Matsusaka, Yoji

AU - Katagiri, Mari

AU - Itoh, Kazunari

AU - Osada, Takashi

AU - Ito, Daisuke

AU - Tabuchi, Hajime

AU - Jinzaki, Masahiro

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