Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs

E. Nakashima, R. Matsushita, T. Ohshima, A. Tsuji, F. Ichimura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To describe quantitatively the peritoneal transport of drugs, the kinetic model, which involves changes in the volume and osmolality of the dialysate as well as the diffusion and convection of drugs across the peritoneum, was applied. The apparent peritoneal permeability (P(d)) of unbound drugs in rats and the partition coefficient (P(app)) in an octanol:water system at pH 7.4 were estimated among acidic drugs. Using the values of unbound fraction (f(S)), the P(d) values of the drugs were estimated from concentration-time profiles in serum and the peritoneal dialysate after intraperitoneal administration of drugs. The intrinsic membrane permeability (P(dm)) was calculated based on a physiological pharmacokinetic model. The f(S)·P(dm) values of thiopental and thiamylal (6.5 and 5.4 ml/min) were 2-3 times greater than the effective peritoneal blood flow, indicating that the peritoneal transport of the barbiturates with high lipophilicity was dominantly blood flow-limited. Evidence shows a high degree of correlation between log P(dm) and log P(app). By considering the relationships, we estimated the P(dm) of quinolonecarboxilic acids. The f(S)·P(dm) values of quinolonecarboxilic acids were <10% of the peritoneal effective blood flow rate, indicating that the peritoneal transport of quinolonecarboxilic acids was dominantly diffusion-limited because of low lipophilicity. In conclusion, there was a good correlation between log P(dm) and log P(app). The prediction of P(dm) can be useful to describe the peritoneal pharmacokinetics.

Original languageEnglish
Pages (from-to)1220-1224
Number of pages5
JournalDrug Metabolism and Disposition
Volume23
Issue number11
Publication statusPublished - 1995
Externally publishedYes

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Physiological Phenomena
Pharmacokinetics
Membranes
Application programs
Pharmaceutical Preparations
Dialysis Solutions
Blood
Acids
Permeability
Thiamylal
Octanols
Convection
Barbiturates
Thiopental
Peritoneum
Osmolar Concentration
Rats
Flow rate
Water
Kinetics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs. / Nakashima, E.; Matsushita, R.; Ohshima, T.; Tsuji, A.; Ichimura, F.

In: Drug Metabolism and Disposition, Vol. 23, No. 11, 1995, p. 1220-1224.

Research output: Contribution to journalArticle

Nakashima, E. ; Matsushita, R. ; Ohshima, T. ; Tsuji, A. ; Ichimura, F. / Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs. In: Drug Metabolism and Disposition. 1995 ; Vol. 23, No. 11. pp. 1220-1224.
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