TY - JOUR
T1 - Quinotrierixin inhibited ER stress-induced XBPl mRNA splicing through inhibition of protein synthesis
AU - Yamamoto, Kohta
AU - Tashiro, Etsu
AU - Imoto, Masaya
N1 - Funding Information:
We thank Dr. Hiroyuki Osada (RIKEN, Japan) for kindly providing us with cytotrienin A. This study was partly supported by grants from Takeda Science Foundation and Suzuken Memorial Foundation. This work was also supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. This study was supported in part by the Global COE Program for Human Metabolomic Systems Biology of MEXT, Japan.
PY - 2011
Y1 - 2011
N2 - Quinotrierixin was isolated from microbes as an inhibitor of ER stress-induced XBPl mRNA splicing, but its mode of action was unclear. We found that quinotrierixin is an inhibitor of protein synthesis, and that the required dose range of quinotrierixin to inhibit ER stress-induced XBPl mRNA splicing was similar to that to inhibit protein synthesis. Furthermore, we also found that quinotrierixin inhibited the ER stress-induced increases of unfolded protein response-related genes such as GRP78, CHOP, EDEM, ERdj4, and p58IPK. Thus, we showed that quinotrierixin inhibited the ER stress-induced unfolded protein response, possibly due to its inhibitory activity of protein synthesis.
AB - Quinotrierixin was isolated from microbes as an inhibitor of ER stress-induced XBPl mRNA splicing, but its mode of action was unclear. We found that quinotrierixin is an inhibitor of protein synthesis, and that the required dose range of quinotrierixin to inhibit ER stress-induced XBPl mRNA splicing was similar to that to inhibit protein synthesis. Furthermore, we also found that quinotrierixin inhibited the ER stress-induced increases of unfolded protein response-related genes such as GRP78, CHOP, EDEM, ERdj4, and p58IPK. Thus, we showed that quinotrierixin inhibited the ER stress-induced unfolded protein response, possibly due to its inhibitory activity of protein synthesis.
KW - ER stress
KW - Protein synthesis inhibitor
KW - Quinotrierixin
KW - XBPl
UR - http://www.scopus.com/inward/record.url?scp=79952167191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952167191&partnerID=8YFLogxK
U2 - 10.1271/bbb.100622
DO - 10.1271/bbb.100622
M3 - Article
C2 - 21307594
AN - SCOPUS:79952167191
SN - 0916-8451
VL - 75
SP - 284
EP - 288
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 2
ER -