Radiation-dose-lowering effects of landiolol hydrochloride in coronary angiography using computed tomography (DELIGHT)

A prospective multicenter study

Teruhito Kido, Teruhito Mochizuki, Masaharu Hirano, Yoshitake Yamada, Ryoichi Tanaka, Suzu Kanzaki, Masahiro Higashi, Masahiro Jinzaki, Kunihiro Yoshioka, Sachio Kuribayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Controlling and decreasing the heart rate (HR) of patients during coronary computed tomography angiography (CCTA) is necessary to reduce radiation exposure and improve image quality. This prospective multicenter study aimed to investigate whether HR control with landiolol hydrochloride is useful for reducing radiation exposure during CCTA. Methods and Results: We investigated 219 patients with suspected ischemic heart disease whose pretest HRs were 50–80 beats/min. We measured the HR before and after administration of landiolol hydrochloride and compared the estimated exposure inferred from the HR before administration of landiolol hydrochloride with the actual dose. After administration of landiolol hydrochloride, the mean HR (59.9 ± 6.4 beats/min) at the time of CCTA was significantly lower than before administration (69.3 ± 7.3 beats/min; P

Original languageEnglish
Pages (from-to)1225-1231
Number of pages7
JournalCirculation Journal
Volume80
Issue number5
DOIs
Publication statusPublished - 2016

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Coronary Angiography
Multicenter Studies
Heart Rate
Tomography
Prospective Studies
Radiation
Myocardial Ischemia
landiolol
Computed Tomography Angiography
Radiation Exposure

Keywords

  • Beta-blockers
  • Coronary computed tomography angiography
  • Ischemic heart disease
  • Landiolol hydrochloride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Radiation-dose-lowering effects of landiolol hydrochloride in coronary angiography using computed tomography (DELIGHT) : A prospective multicenter study. / Kido, Teruhito; Mochizuki, Teruhito; Hirano, Masaharu; Yamada, Yoshitake; Tanaka, Ryoichi; Kanzaki, Suzu; Higashi, Masahiro; Jinzaki, Masahiro; Yoshioka, Kunihiro; Kuribayashi, Sachio.

In: Circulation Journal, Vol. 80, No. 5, 2016, p. 1225-1231.

Research output: Contribution to journalArticle

Kido, Teruhito ; Mochizuki, Teruhito ; Hirano, Masaharu ; Yamada, Yoshitake ; Tanaka, Ryoichi ; Kanzaki, Suzu ; Higashi, Masahiro ; Jinzaki, Masahiro ; Yoshioka, Kunihiro ; Kuribayashi, Sachio. / Radiation-dose-lowering effects of landiolol hydrochloride in coronary angiography using computed tomography (DELIGHT) : A prospective multicenter study. In: Circulation Journal. 2016 ; Vol. 80, No. 5. pp. 1225-1231.
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AU - Hirano, Masaharu

AU - Yamada, Yoshitake

AU - Tanaka, Ryoichi

AU - Kanzaki, Suzu

AU - Higashi, Masahiro

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AU - Yoshioka, Kunihiro

AU - Kuribayashi, Sachio

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AB - Background: Controlling and decreasing the heart rate (HR) of patients during coronary computed tomography angiography (CCTA) is necessary to reduce radiation exposure and improve image quality. This prospective multicenter study aimed to investigate whether HR control with landiolol hydrochloride is useful for reducing radiation exposure during CCTA. Methods and Results: We investigated 219 patients with suspected ischemic heart disease whose pretest HRs were 50–80 beats/min. We measured the HR before and after administration of landiolol hydrochloride and compared the estimated exposure inferred from the HR before administration of landiolol hydrochloride with the actual dose. After administration of landiolol hydrochloride, the mean HR (59.9 ± 6.4 beats/min) at the time of CCTA was significantly lower than before administration (69.3 ± 7.3 beats/min; P

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