Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT

Toshiaki Takeda, Atsuya Takeda, Etsuo Kunieda, Akitoshi Ishizaka, Kazuhiko Takemasa, Kyoko Shimada, Seika Yamamoto, Naoyuki Shigematsu, Osamu Kawaguchi, Junichi Fukada, Toshio Ohashi, Sachio Kuribayashi, Atsushi Kubo

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

OBJECTIVE. We studied the serial changes and CT manifestations of pulmonary radiation injury after hypofractionated stereotactic radiation therapy for peripheral small lung tumors. SUBJECTS AND METHODS. Hypofractionated stereotactic radiation therapy was applied to 20 patients with proven primary (n = 11) or metastatic (n = 9) lung cancer, for a total of 22 lesions of 3 cm or less in diameter located within 3 cm from the parietal pleural surface. Follow-up CT was scheduled at 1 and 3 months, and every 3 months thereafter. RESULTS. Ground-glass opacities were observed around four (18%) of 22 lesions at 3-6 months. The opacities nearly corresponded to the planned target volume, but half of them were unevenly distributed. Ground-glass opacities gradually disappeared or evolved into dense consolidation while shrinking. Dense consolidations developed in 16 (73%) of 22 lesions, including seven in the center of the planned target volume and nine in the periphery of the planned target volume. Dense consolidations moved in six of these 16 lesions and gradually shrank, becoming fixed as solid or linear opacities approximately 12 months later. CONCLUSION. The pulmonary opacities observed after hypofractionated stereotactic radiation therapy for peripheral small lung tumors may not precisely correspond to the planned target volume (unlike those with conventional radiation therapy) and may change in shape and location dynamically during the first year. Knowledge of these findings is necessary to avoid misunderstandings concerning tumor regrowth or new tumors.

Original languageEnglish
Pages (from-to)1123-1128
Number of pages6
JournalAmerican Journal of Roentgenology
Volume182
Issue number5
Publication statusPublished - 2004 May

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Radiation Injuries
Radiotherapy
Lung
Glass
Neoplasms
Lung Injury
Lung Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Takeda, T., Takeda, A., Kunieda, E., Ishizaka, A., Takemasa, K., Shimada, K., ... Kubo, A. (2004). Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT. American Journal of Roentgenology, 182(5), 1123-1128.

Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors : Serial Changes on CT. / Takeda, Toshiaki; Takeda, Atsuya; Kunieda, Etsuo; Ishizaka, Akitoshi; Takemasa, Kazuhiko; Shimada, Kyoko; Yamamoto, Seika; Shigematsu, Naoyuki; Kawaguchi, Osamu; Fukada, Junichi; Ohashi, Toshio; Kuribayashi, Sachio; Kubo, Atsushi.

In: American Journal of Roentgenology, Vol. 182, No. 5, 05.2004, p. 1123-1128.

Research output: Contribution to journalArticle

Takeda, T, Takeda, A, Kunieda, E, Ishizaka, A, Takemasa, K, Shimada, K, Yamamoto, S, Shigematsu, N, Kawaguchi, O, Fukada, J, Ohashi, T, Kuribayashi, S & Kubo, A 2004, 'Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT', American Journal of Roentgenology, vol. 182, no. 5, pp. 1123-1128.
Takeda T, Takeda A, Kunieda E, Ishizaka A, Takemasa K, Shimada K et al. Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT. American Journal of Roentgenology. 2004 May;182(5):1123-1128.
Takeda, Toshiaki ; Takeda, Atsuya ; Kunieda, Etsuo ; Ishizaka, Akitoshi ; Takemasa, Kazuhiko ; Shimada, Kyoko ; Yamamoto, Seika ; Shigematsu, Naoyuki ; Kawaguchi, Osamu ; Fukada, Junichi ; Ohashi, Toshio ; Kuribayashi, Sachio ; Kubo, Atsushi. / Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors : Serial Changes on CT. In: American Journal of Roentgenology. 2004 ; Vol. 182, No. 5. pp. 1123-1128.
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abstract = "OBJECTIVE. We studied the serial changes and CT manifestations of pulmonary radiation injury after hypofractionated stereotactic radiation therapy for peripheral small lung tumors. SUBJECTS AND METHODS. Hypofractionated stereotactic radiation therapy was applied to 20 patients with proven primary (n = 11) or metastatic (n = 9) lung cancer, for a total of 22 lesions of 3 cm or less in diameter located within 3 cm from the parietal pleural surface. Follow-up CT was scheduled at 1 and 3 months, and every 3 months thereafter. RESULTS. Ground-glass opacities were observed around four (18{\%}) of 22 lesions at 3-6 months. The opacities nearly corresponded to the planned target volume, but half of them were unevenly distributed. Ground-glass opacities gradually disappeared or evolved into dense consolidation while shrinking. Dense consolidations developed in 16 (73{\%}) of 22 lesions, including seven in the center of the planned target volume and nine in the periphery of the planned target volume. Dense consolidations moved in six of these 16 lesions and gradually shrank, becoming fixed as solid or linear opacities approximately 12 months later. CONCLUSION. The pulmonary opacities observed after hypofractionated stereotactic radiation therapy for peripheral small lung tumors may not precisely correspond to the planned target volume (unlike those with conventional radiation therapy) and may change in shape and location dynamically during the first year. Knowledge of these findings is necessary to avoid misunderstandings concerning tumor regrowth or new tumors.",
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AU - Ishizaka, Akitoshi

AU - Takemasa, Kazuhiko

AU - Shimada, Kyoko

AU - Yamamoto, Seika

AU - Shigematsu, Naoyuki

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AU - Fukada, Junichi

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N2 - OBJECTIVE. We studied the serial changes and CT manifestations of pulmonary radiation injury after hypofractionated stereotactic radiation therapy for peripheral small lung tumors. SUBJECTS AND METHODS. Hypofractionated stereotactic radiation therapy was applied to 20 patients with proven primary (n = 11) or metastatic (n = 9) lung cancer, for a total of 22 lesions of 3 cm or less in diameter located within 3 cm from the parietal pleural surface. Follow-up CT was scheduled at 1 and 3 months, and every 3 months thereafter. RESULTS. Ground-glass opacities were observed around four (18%) of 22 lesions at 3-6 months. The opacities nearly corresponded to the planned target volume, but half of them were unevenly distributed. Ground-glass opacities gradually disappeared or evolved into dense consolidation while shrinking. Dense consolidations developed in 16 (73%) of 22 lesions, including seven in the center of the planned target volume and nine in the periphery of the planned target volume. Dense consolidations moved in six of these 16 lesions and gradually shrank, becoming fixed as solid or linear opacities approximately 12 months later. CONCLUSION. The pulmonary opacities observed after hypofractionated stereotactic radiation therapy for peripheral small lung tumors may not precisely correspond to the planned target volume (unlike those with conventional radiation therapy) and may change in shape and location dynamically during the first year. Knowledge of these findings is necessary to avoid misunderstandings concerning tumor regrowth or new tumors.

AB - OBJECTIVE. We studied the serial changes and CT manifestations of pulmonary radiation injury after hypofractionated stereotactic radiation therapy for peripheral small lung tumors. SUBJECTS AND METHODS. Hypofractionated stereotactic radiation therapy was applied to 20 patients with proven primary (n = 11) or metastatic (n = 9) lung cancer, for a total of 22 lesions of 3 cm or less in diameter located within 3 cm from the parietal pleural surface. Follow-up CT was scheduled at 1 and 3 months, and every 3 months thereafter. RESULTS. Ground-glass opacities were observed around four (18%) of 22 lesions at 3-6 months. The opacities nearly corresponded to the planned target volume, but half of them were unevenly distributed. Ground-glass opacities gradually disappeared or evolved into dense consolidation while shrinking. Dense consolidations developed in 16 (73%) of 22 lesions, including seven in the center of the planned target volume and nine in the periphery of the planned target volume. Dense consolidations moved in six of these 16 lesions and gradually shrank, becoming fixed as solid or linear opacities approximately 12 months later. CONCLUSION. The pulmonary opacities observed after hypofractionated stereotactic radiation therapy for peripheral small lung tumors may not precisely correspond to the planned target volume (unlike those with conventional radiation therapy) and may change in shape and location dynamically during the first year. Knowledge of these findings is necessary to avoid misunderstandings concerning tumor regrowth or new tumors.

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