Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia

K. Ozawa, Y. Miura, T. Suda, K. Motoyoshi, F. Takaku

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The radiation sensitivity of leukemic progenitor cells in 12 cases of acute nonlymphocytic leukemia was compared with that of normal myeloid progenitor cells (colony-forming units in culture), using in vitro cloning techniques. The D(d) value for normal colony-forming units in culture was almost constant (130 ± 14 rads). On the other hand, marked patient-to-patient variations were observed in the radiosensitivity of leukemic progenitor cells; namely, the D(o) values in the present cases ranged from 30 to 210 rads. These variations seemed to be partly due to different cell cycle status and partly due to the intrinsic nature of leukemic progenitor cells. Moreover, in six of seven clinically drug-sensitive cases, the leukemic progenitor cells were proved to be relatively radiosensitive. Similar to in vitro drug sensitivity tests, this test may serve to predict the clinical response to chemoradiotherapy.

Original languageEnglish
Pages (from-to)2339-2341
Number of pages3
JournalCancer Research
Volume43
Issue number5
Publication statusPublished - 1983

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Radiation Tolerance
Acute Myeloid Leukemia
Stem Cells
Myeloid Progenitor Cells
Chemoradiotherapy
Pharmaceutical Preparations
Organism Cloning
Cell Cycle
Reference Values

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ozawa, K., Miura, Y., Suda, T., Motoyoshi, K., & Takaku, F. (1983). Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia. Cancer Research, 43(5), 2339-2341.

Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia. / Ozawa, K.; Miura, Y.; Suda, T.; Motoyoshi, K.; Takaku, F.

In: Cancer Research, Vol. 43, No. 5, 1983, p. 2339-2341.

Research output: Contribution to journalArticle

Ozawa, K, Miura, Y, Suda, T, Motoyoshi, K & Takaku, F 1983, 'Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia', Cancer Research, vol. 43, no. 5, pp. 2339-2341.
Ozawa K, Miura Y, Suda T, Motoyoshi K, Takaku F. Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia. Cancer Research. 1983;43(5):2339-2341.
Ozawa, K. ; Miura, Y. ; Suda, T. ; Motoyoshi, K. ; Takaku, F. / Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia. In: Cancer Research. 1983 ; Vol. 43, No. 5. pp. 2339-2341.
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