Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia

Keiya Ozawa, Yasusada Miura, Toshio Suda, Kazuo Motoyoshi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The radiation sensitivity of leukemic progenitor cells in 12 cases of acute nonlymphocytic leukemia was compared with that of normal myeloid progenitor cells (colony-forming units in culture), using in vitro cloning techniques. The D0value for normal colony-forming units in culture was almost constant (130 ± 14 rads). On the other hand, marked patient-to-patient variations were observed in the radiosensitivity of leukemic progenitor cells; namely, the D0values in the present cases ranged from 30 to 210 rads. These variations seemed to be partly due to different cell cycle status and partly due to the intrinsic nature of leukemic progenitor cells. Moreover, in six of seven clinically drug-sensitive cases, the leukemic progenitor cells were proved to be relatively radiosensitive. Similar to in vitro drug sensitivity tests, this test may serve to predict the clinical response to chemoradiotherapy.

Original languageEnglish
Pages (from-to)2339-2341
Number of pages3
JournalCancer Research
Volume43
Issue number5
Publication statusPublished - 1983 May 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia'. Together they form a unique fingerprint.

  • Cite this

    Ozawa, K., Miura, Y., Suda, T., & Motoyoshi, K. (1983). Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia. Cancer Research, 43(5), 2339-2341.