Radical radiotherapy with or without chemotherapy for hypopharyngeal carcinoma

Atsunori Yorozu, Kazuhito Toya, Junichi Fukada, Takushi Dokiya

Research output: Contribution to journalArticle

Abstract

We took a routine conservative approach for hypopharyngeal carcinoma. This retrospective study analyzes the outcome of treatment with this policy. Between 1993 and 2002, 36 patients with hypopharyngeal carcinoma received radiotherapy with or without chemotherapy at our institution. Doses ranged from 60 Gy to 72 Gy given to the involved fields. Fourteen patients received CDDP and 5FU, either inductive or concurrent with radiotherapy. The overall five-year survival was 38% and the two-year local control rate was 69%. The local control rate was dependent on the size of primary tumor. Two-year local control rates were 60% with radiotherapy alone and 88% with chemoradiotherapy. Neck dissections combined with radiotherapy were all successful for 12 patients with N1-2. In 14 patients with N0, 3 patients were salvaged successfully after nodal recurrence. Ultimate conservation rate of laryngo-pharynx was 67%. This non-surgical therapy provided survival comparable with that achieved with the standard approach of surgery and postoperative radiotherapy.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalJournal of JASTRO
Volume16
Issue number2
Publication statusPublished - 2004 Jun

Fingerprint

Radiotherapy
Carcinoma
Drug Therapy
Neck Dissection
Survival
Chemoradiotherapy
Pharynx
Fluorouracil
Retrospective Studies
Recurrence
Neoplasms
Therapeutics

Keywords

  • Chemoradiotherapy
  • Hypopharyngeal carcinoma
  • Radiotherapy
  • Salvage surgery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Radical radiotherapy with or without chemotherapy for hypopharyngeal carcinoma. / Yorozu, Atsunori; Toya, Kazuhito; Fukada, Junichi; Dokiya, Takushi.

In: Journal of JASTRO, Vol. 16, No. 2, 06.2004, p. 91-94.

Research output: Contribution to journalArticle

Yorozu, Atsunori ; Toya, Kazuhito ; Fukada, Junichi ; Dokiya, Takushi. / Radical radiotherapy with or without chemotherapy for hypopharyngeal carcinoma. In: Journal of JASTRO. 2004 ; Vol. 16, No. 2. pp. 91-94.
@article{85b8a815839a45799067487038600df5,
title = "Radical radiotherapy with or without chemotherapy for hypopharyngeal carcinoma",
abstract = "We took a routine conservative approach for hypopharyngeal carcinoma. This retrospective study analyzes the outcome of treatment with this policy. Between 1993 and 2002, 36 patients with hypopharyngeal carcinoma received radiotherapy with or without chemotherapy at our institution. Doses ranged from 60 Gy to 72 Gy given to the involved fields. Fourteen patients received CDDP and 5FU, either inductive or concurrent with radiotherapy. The overall five-year survival was 38{\%} and the two-year local control rate was 69{\%}. The local control rate was dependent on the size of primary tumor. Two-year local control rates were 60{\%} with radiotherapy alone and 88{\%} with chemoradiotherapy. Neck dissections combined with radiotherapy were all successful for 12 patients with N1-2. In 14 patients with N0, 3 patients were salvaged successfully after nodal recurrence. Ultimate conservation rate of laryngo-pharynx was 67{\%}. This non-surgical therapy provided survival comparable with that achieved with the standard approach of surgery and postoperative radiotherapy.",
keywords = "Chemoradiotherapy, Hypopharyngeal carcinoma, Radiotherapy, Salvage surgery",
author = "Atsunori Yorozu and Kazuhito Toya and Junichi Fukada and Takushi Dokiya",
year = "2004",
month = "6",
language = "English",
volume = "16",
pages = "91--94",
journal = "Journal of JASTRO",
issn = "1040-9564",
publisher = "Editorial Board of JASTRO",
number = "2",

}

TY - JOUR

T1 - Radical radiotherapy with or without chemotherapy for hypopharyngeal carcinoma

AU - Yorozu, Atsunori

AU - Toya, Kazuhito

AU - Fukada, Junichi

AU - Dokiya, Takushi

PY - 2004/6

Y1 - 2004/6

N2 - We took a routine conservative approach for hypopharyngeal carcinoma. This retrospective study analyzes the outcome of treatment with this policy. Between 1993 and 2002, 36 patients with hypopharyngeal carcinoma received radiotherapy with or without chemotherapy at our institution. Doses ranged from 60 Gy to 72 Gy given to the involved fields. Fourteen patients received CDDP and 5FU, either inductive or concurrent with radiotherapy. The overall five-year survival was 38% and the two-year local control rate was 69%. The local control rate was dependent on the size of primary tumor. Two-year local control rates were 60% with radiotherapy alone and 88% with chemoradiotherapy. Neck dissections combined with radiotherapy were all successful for 12 patients with N1-2. In 14 patients with N0, 3 patients were salvaged successfully after nodal recurrence. Ultimate conservation rate of laryngo-pharynx was 67%. This non-surgical therapy provided survival comparable with that achieved with the standard approach of surgery and postoperative radiotherapy.

AB - We took a routine conservative approach for hypopharyngeal carcinoma. This retrospective study analyzes the outcome of treatment with this policy. Between 1993 and 2002, 36 patients with hypopharyngeal carcinoma received radiotherapy with or without chemotherapy at our institution. Doses ranged from 60 Gy to 72 Gy given to the involved fields. Fourteen patients received CDDP and 5FU, either inductive or concurrent with radiotherapy. The overall five-year survival was 38% and the two-year local control rate was 69%. The local control rate was dependent on the size of primary tumor. Two-year local control rates were 60% with radiotherapy alone and 88% with chemoradiotherapy. Neck dissections combined with radiotherapy were all successful for 12 patients with N1-2. In 14 patients with N0, 3 patients were salvaged successfully after nodal recurrence. Ultimate conservation rate of laryngo-pharynx was 67%. This non-surgical therapy provided survival comparable with that achieved with the standard approach of surgery and postoperative radiotherapy.

KW - Chemoradiotherapy

KW - Hypopharyngeal carcinoma

KW - Radiotherapy

KW - Salvage surgery

UR - http://www.scopus.com/inward/record.url?scp=3242781887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242781887&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 91

EP - 94

JO - Journal of JASTRO

JF - Journal of JASTRO

SN - 1040-9564

IS - 2

ER -